摘要
胆固醇是细胞多元复合物中的变色龙生物分子。它几乎以其特定部位的特征在每个细胞室中充当先导作用。生物膜的结构准确性和支架流动性的调节,神经电传导的绝缘,通过制备类固醇内分泌激素来控制基因,充当代谢调节剂的前体,以及在细胞核中不断出现的预言以驱动新细胞形成的更多功能。除了在细胞功能方面至关重要的传统外,胆固醇还被排斥为LDL颗粒的成员,这已被证明可导致血管阻塞。由于血管壁和周围组织上无功能的LDL受体,LDL颗粒的清除能力差,因此LDL颗粒沉积在血管中。血管阻塞促进心脏病发作和中风。另一方面,胆固醇已被列为促癌分子。在这个阶段,胆固醇又是两相的。尽管胆固醇对于构建核膜及其脂质移植物至关重要。在癌症肿瘤细胞中,胆固醇不受细胞内反馈调节的控制,而是通过穿过核膜并促进细胞增殖而积累在细胞核内。在癌前期,由于缺乏必要的细胞内和核内胆固醇池浓度,免疫细胞也会死亡。已经在核膜,染色体的位置和核质中发现了细胞核中胆固醇的存在。据报道,核筏微域中胆固醇的存在与基因转录,细胞增殖和凋亡有关。胆固醇结构域中胆固醇酯的水解与新生细胞的产生有关。显然,胆固醇现在也已经成为细胞核的主要产物------细胞港中的偶然事件。
关键词: 胆固醇,低密度脂蛋白,低密度脂蛋白受体,细胞核,细胞增殖,核脂质。
Current Molecular Medicine
Title:Cholesterol: A Prelate in Cell Nucleus and its Serendipity
Volume: 20 Issue: 9
关键词: 胆固醇,低密度脂蛋白,低密度脂蛋白受体,细胞核,细胞增殖,核脂质。
摘要: Cholesterol is a chameleon bio-molecule in cellular multiplex. It acts as a prelate in almost every cellular compartment with its site specific characteristics viz. regulation of structural veracity and scaffold fluidity of bio-membranes, insulation of electrical transmission in nerves, controlling of genes by making steroid endocrines, acting as precursors of metabolic regulators and many more with its emerging prophecy in the cell nucleus to drive new cell formation. Besides the crucial legacy in cellular functionality, cholesterol is ostracized as a member of LDL particle, which has been proved responsible to clog blood vessels. LDL particles get deposited in the blood vessels because of their poor clearance owing to the non-functioning LDL receptor on the vessel wall and surrounding tissues. Blocking of blood vessel promotes heart attack and stroke. On the other hand, cholesterol has been targeted as pro-cancerous molecule. At this phase again cholesterol is biphasic. Although cholesterol is essential to construct nuclear membrane and its lipid-rafts; in cancer tumour cells, cholesterol is not under the control of intracellular feedback regulation and gets accumulated within cell nucleus by crossing nuclear membrane and promoting cell proliferation. In precancerous stage, the immune cells also die because of the lack of requisite concentration of intracellular and intranuclear cholesterol pool. The existence of cholesterol within the cell nucleus has been found in the nuclear membrane, epichromosomal location and nucleoplasm. The existence of cholesterol in the microdomain of nuclear raft has been reported to be linked with gene transcription, cell proliferation and apoptosis. Hydrolysis of cholesterol esters in chromosomal domain is linked with new cell generation. Apparently, Cholesterol is now a prelate in cell nucleus too ------ A serendipity in cellular haven.
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Cholesterol: A Prelate in Cell Nucleus and its Serendipity, Current Molecular Medicine 2020; 20 (9) . https://dx.doi.org/10.2174/1566524020666200413112030
DOI https://dx.doi.org/10.2174/1566524020666200413112030 |
Print ISSN 1566-5240 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5666 |
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