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Current Enzyme Inhibition


ISSN (Print): 1573-4080
ISSN (Online): 1875-6662

Review Article

Recent Progress and Development of Small Molecule Kinase Inhibitors for the Treatment of Breast Cancer

Author(s): Debasis Das* and Jian Hong

Volume 16 , Issue 1 , 2020

Page: [4 - 19] Pages: 16

DOI: 10.2174/1573408016666200228112728

Price: $65


Breast cancer, the most common health burden to women globally, is considered a major cause of death for women every year. Many signal transduction pathways can cause breast cancer. The kinase inhibitors can interrupt the signaling pathways, minimize tumor growth and consequently cure the disease. The scientists have discovered many kinase inhibitors as targeted drugs for breast cancer. In recent years, the inhibitors of EGFR, HER2, VEGFR, PI3K, CDK4/6, PARP and hormone receptor have been studied well for curing breast cancer. The FDA has approved a few kinase drugs such as trastuzumab, lapatinib, neratinib, palbociclib, abemaciclib, alpelisib to treat breast cancer recently. In this review, we summarized the latest development of kinase inhibitors as breast cancer therapy.

Keywords: Breast cancer, CDK4/6, HER2, inhibitor, kinase, PI3K, signal transduction.

Graphical Abstract
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