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Current Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

COX-2 Selectivity and Inflammatory Processes

Author(s): Joanne van Ryn, Gnnter Trummlitz and Michel Pairet

Volume 7 , Issue 11 , 2000

Page: [1145 - 1161] Pages: 17

DOI: 10.2174/0929867003374255

Price: $65

Abstract

Increasing amounts of experimental and clinical data support the role of selective cyclooxygenase (COX)-2 inhibition in anti-inflammatory processes and the involvement of COX-1 inhibition in the side effects. associated with non steroidal anti-inflammatory drug use. This review will focus on the differences in the structure of the COX-1 and COX-2 molecules, particularly the active site and how they are bound by various NSAIDs to achieve COX-2 selectivity. This COX-2 selectivity will then be characterized in pharmacological assays in vitro and in animal models in vivo. Finally, clinical information available for this new class of selective inhibitors will be discussed.


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