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Cardiovascular & Hematological Agents in Medicinal Chemistry


ISSN (Print): 1871-5257
ISSN (Online): 1875-6182

Review Article

A Review on Phytochemistry, Pharmacological Action, Ethanobotanical Uses and Nutritional Potential of Kedrostis foetidissima (Jacq.) Cogn.,

Author(s): Kalaiseziyen Pavithra and Ganapathy Saravanan*

Volume 18, Issue 1, 2020

Page: [5 - 20] Pages: 16

DOI: 10.2174/1871525718666200212095353

Price: $65


Nature is an amazing source for food, shelter, clothing and medicine. An impressive number of modern drugs are isolated from many sources like plants, animals and microbes. The development of natural products from traditional medicines is of great importance to society. Modern concepts and methodologies with abundant clinical studies, unique diversity of chemical structures and biological activities aid the modern drug discovery process. Kedrostis foetidissima (Jacq.) Cogn., a traditional medicinal plant of the Cucurbitaceae family, is found in India, Sri Lanka, Ethiopia and Western Malaysia. Almost all parts of the plant are used in traditional systems of medicines and reported having medicinal properties in both in vitro and in vivo studies. In the last few years, extensive research work had been carried out using extracts and isolated phytoconstituents from Kedrostis foetidissima to confirm its pharmacology and biological activities. Many scientific reports show that crude extracts and extensive numbers of phytochemical constituents isolated from Kedrostis foetidissima have activities like antimicrobial, antioxidant, anticancer, gastroprotective, anti-inflammatory and various other important medicinal properties. The therapeutic properties of the plants are mainly attributed to the existence of phytoconstituents like phenols, alkaloids, flavonoids, tannins, terpenoids and steroids. This comprehensive review in various aspects gave a brief overview of phytoconstituents, nutritional values and medicinal property of the plant and might attract the researchers to explore its medicinal activity by discovering novel biologically active compounds that can serve as a lead compound in pharmaceutical and food industry.

Keywords: Antioxidants, bioactive molecules, cucurbitaceae, Kedrostis, phytochemical, phytoconstituents.

Graphical Abstract
Palhares, R.M.; Gonçalves Drummond, M.; Dos Santos Alves Figueiredo Brasil, B.; Pereira Cosenza, G.; das Graças Lins Brandão, M.; Oliveira, G. Medicinal plants recommended by the world health organization: DNA barcode identification associated with chemical analyses guarantees their quality. PLoS One, 2015, 10(5), e0127866
[] [PMID: 25978064]
Liu, Y.T.; Zhou, C.; Jia, H.M.; Chang, X.; Zou, Z.M. Standardized Chinese Formula Xin-Ke-Shu inhibits the myocardium Ca2+ overloading and metabolic alternations in isoproterenol-induced myocardial infarction rats. Sci. Rep., 2016, 6, 1-5.
Modi, A.; Kumar, V. Luffa echinata Roxb. - A review on its ethanomedicinal, phytochemical and pharmacological perspective. Asian Pac. J. Trop. Dis., 2014, 4(Suppl. 1), 7-12.
Pal, S.K.; Shukla, Y. Herbal medicine: current status and the future. Asian Pac. J. Cancer Prev., 2003, 4(4), 281-288.
[PMID: 14728584]
Jamuna, S.; Karthika, K.; Paulsamy, S. Phytochemical and pharmacological properties of certain medicinally important species of Cucurbitaceae family – A review. J. Res. Biol., 2015, 5(6), 1835-1849.
Zaini, N.; Anwar, F.; Amid, A.; Saari, N. Kundur. Benincasa hispida (Thunb.) Cogn.: A potential source for valuable nutrients and functional foods. Food Res. Int., 2011, 44(7), 2368-2376.
Amutha, M.; Lalitha, P. Review on Kedrostis foetidissima (Jacq.) Cogn. J. Pharm. Res., 2012, 5(5), 644-648.
Giday, M.; Asfaw, Z.; Elmqvist, T.; Woldu, Z. An ethnobotanical study of medicinal plants used by the Zay people in Ethiopia. Skriftserie, 2001, 3, 81-99.
Karuppusamy, S. Medicinal plants used by Paliyan tribes of Sirumalai hills of southern India. Nat. Prod. Radiance, 2007, 6(5), 436-442.
Ragupathy, S.; Steven, N.G.; Maruthakkutti, M.; Velusamy, B.; Ul-Huda, M.M. Consensus of the ‘Malasars’ traditional aboriginal knowledge of medicinal plants in the Velliangiri holy hills, India. J. Ethnobiol. Ethnomed., 2008, 4(8), 8.
[] [PMID: 18371206]
Tabuti, J.R.S.; Lye, K.A.; Dhillion, S.S. Traditional herbal drugs of Bulamogi, Uganda: plants, use and administration. J. Ethnopharmacol., 2003, 88(1), 19-44.
[] [PMID: 12902048]
Renner, S.S.; Pandey, A.K. The Cucurbitaceae of India: Accepted names, synonyms, geographic distribution, and information on images and DNA sequences. PhytoKeys, 2013, 20(20), 53-118.
[] [PMID: 23717193]
Nirmala, J.; Pandian, R. Morphological and systematic studies on Kedrostis foetidissima (Jacq.) Cogn. Int. J. Curr. Microbiol. Appl. Sci., 2013, 2(10), 560-571.
Ganesan, S.; Suresh, N.; Kesavan, L. Ethnomedicinal survey of lower Palni Hills of Tamilnadu. Indian J. Tradit. Knowl., 2004, 3(3), 299-304.
Ayyanar, M.; Ignacimuthu, S. Ethnomedicinal plants used by the tribals of Tirunelveli hills to treat poisonous bites and skin diseases. Indian J. Tradit. Knowl., 2005, 4(3), 229-236.
Rajendran, K.; Gunasekaran, T. Common and cultivated medicinal plants and their utilization by villagers in Southern districts of Tamil Nadu. Indian For., 2006, 132(12), 1631-1637.
Friedman, J.; Bolotin, D.; Rios, M.; Mendosa, P.; Cohen, Y.; Balick, M.J. A novel method for identification and domestication of indigenous useful plants in Amazonian Ecuador. In: New Crops, ; 1st. Ed.: Janick, J.; Simon, J. Eds.; . John Wiley and Sons Inc.: NewYork, , 1993, pp. 167-174.
Zinyama, L.M.; Matiza, T.; Campbell, D.J. The use of wild foods during periods of food shortage in rural Zimbabwe. Ecol. Food Nutr., 1990, 24, 251-265.
Johns, T.; Kokwaro, J.O. Food plants of the Luo of Siaya District, Kenya. Econ. Bot., 1999, 45(1), 103-113.
Teklehaymanot, T.; Giday, M. Ethnobotanical study of wild edible plants of Kara and Kwego semi-pastoralist people in lower Omo river valley, Debub Omo Zone, SNNPR, Ethiopia. J. Ethnobiol. Ethnomed., 2010, 6(23), 23.
[] [PMID: 20712910]
Otieno, D.A.; Odero, B.N. Antibiotic constituents from Kedrostis foetidissima. (PA94). In: International Symposium on the Chemistry of Natural Products, 1988, 172, pp. pp. 5-29.
Ole-Miaron, J.O. The Maasai ethnodiagnostic skill of livestock diseases: a lead to traditional bioprospecting. J. Ethnopharmacol., 2003, 84(1), 79-83.
[] [PMID: 12499079]
Otieno, J.N.; Hosea, K.M.; Lyaruu, H.V.; Mahunnah, R.L. Multi-plant or single-plant extracts, which is the most effective for local healing in Tanzania? Afr. J. Tradit. Complement. Altern. Med., 2008, 5(2), 165-172.
[] [PMID: 20161933]
Dymock, W. Pharmacogeaphia Indica, 1891, 2(97), 90-92.
Kamatenesi, M.M.; Acipa, A.; Oryem-Origa, H. Medicinal plants of Otwal and Ngai sub counties in Oyam district, Northern Uganda. J. Ethnobiol. Ethnomed., 2011, 7(7), 7.
[] [PMID: 21241484]
Cocks, M.L.; Dold, A.P. Cultural significance of biodiversity: The role of medicinal plants in urban African cultural practices in the castern cape, South Africa. J. Ethnobiol., 2006, 26(1), 60-81.
Kavitha, R.; Chittibabu, C.V.; Subha, T.S. In vitro antibacterial activity and phytochemical composition of Kedrostis foetidissima (Jacq.). Cogn. Ind. J. Drugs Diseases, 2014, 3(1), 11-18.
Jagadeeswari, M.; Hemashenpagam, N. Qualitative and quantitative phytochemical analysis of Kedrostis foetidissima (Jacq.) Cogn., leaf extracts. Int. J. Basic Appl. Res., 2018, 8(7), 458-466.
Vasantha, K.; Priyavardhini, S.; Tresina Soris, P.; Mohan, V.R. Phytochemical analysis and antibacterial activity of Kedrostis foetidissima (Jacq.) Cogn. Biosci. Disc., 2012, 3(1), 06-16.
Sharly Elgal, N.; Arulkumar, L.; Jasmine, R. Phytochemical and antibacterial analysis of Kedrostis foetidissima against a few respiratory isolates. World J. Pharm. Pharm. Sci., 2014, 3(4), 1066-1071.
Kalaisezhiyen, P.; Sasikumar, V. GC-MS evaluation of chemical constituents from methanolic leaf extract of Kedrostis foetidissima (Jacq.) Cogn. Asian J. Pharmaceut. Clin. Res., 2012, 5(4), 77-81.
Dunnill, P.M.; Fowden, L. The amino acids of seeds of the cucurbitacae. Phytochemistry, 1965, 4, 933-944.
Miro, M. Curcubitacins and their pharmalogical effects. Phytother. Res., 1995, 9(3), 159-168.
Amutha, M. Phytochemical, biological, pharmacological evaluation of Kedrostis foetidissima (Jacq.) Cogn. and plant-mediated synthesis of metal nanoparticles.. Ph.D Thesis, Avinashilingam Institute for Home Science and Higher Education for Women, Coimbatore., 2017.
Nirmala, J.; Pandian, R.; Jayaraman, P. Pharmacognostical and histo chemical analysis of entire plant of Kedrostis foeditissima (Jacq.) Cogn. Cucurbitaceae. Int. J. Curr. Res. Acad. Rev., 2015, 3(7), 91-100.
Raja, M.J.; Arivuchelvan, A.; Jagadeeswaran, A.; Sukumar, K.; Sivaseelan, S. Exploration of the physio-chemical properties of Kedrostis foetidissima (Jacq.) Cogn. herb by proximate and qualitative phytochemical analysis. Int. J. Advan. Vet. Sci. Technol., 2016, 5(2), 270-274.
Mohan, V.R.; Kalidass, C. Nutritional and antinutritional evaluation of some unconventional wild edible plants. Trop. Subtrop. Agroecosystems, 2010, 12, 495-506.
National Research Council. Recommended Dietary Allowances, 9th Ed; National Academy of Science Press: Washington, DC, USA, 1980.
Alagumuthu, G.; Kirubha, R. Green synthesis of silver nanoparticles using Cissus quadrangularis plant extract and their antibacterial activity. Int. J. Nanomater. Biostruct., 2012, 3, 30-33.
Amutha, M.; Lalitha, P.; Firdhouse, M.J. Biosynthesis of silver nanoparticles using Kedrostis foetidissima (Jacq.) Cogn; J. Nanotech, 2014, pp. 1-5.
Subramani, V.; Jeyakumar, J.J.; Kamaraj, M.; Ramachandran, B. Plant extracts derived silver nanoparticles. Int. J. Pharma Res. Review, 2014, 3(3), 16-19.
Nirmala, J.; Pandian, R. Extraction and characterization of nano particles synthesized using plant extract of Kedrostis foeditissima (Jacq). Lin. Int. J. Curr. Microbiol. Appl. Sci., 2015, 4(4), 41-47.
Firdhouse, M.J.; Lalitha, P. Biocidal potential of biosynthesized silver nanoparticles against fungal threats. J. Nanostruct. Chem., 2015, 5, 25-33.
Sharmila Devi, R.; Dhinesh, R. Rapid green synthesis of zinc oxide nanoparticles using Kedrostis foetidissima (Jacq.) Cogn. leaf. Int. J. Innov. Res. Sci. Engin. and Tech., 2016, 5(11), 19281-19285.
Geetharani, S. Synthesis of ZnO-HNPS for functional fabric finishing using Zinc-herbal nano complex. Int. J. Res. Engin. Sci. and Manage., 2019, 2(4), 487-491.
Firdhouse, M.J.; Lalitha, P. Flower-shaped gold nanoparticles synthesized using Kedrostis foetidissima and their antiproliferative activity against bone cancer cell lines. Int. J. Indust. Chem., 2016, 7, 347-358.
Alagesan, K.; Raghupathi, P.K.; Sankarnarayanan, S. Amylase inhibitors: Potential source of anti-diabetic drug discovery from medicinal plants. Int. J. Pharm. Life Sci., 2012, 3(2), 1407-1412.
Wadkar, K.A.; Magdum, C.S.; Patil, S.S.; Naikwade, N.S. Anti diabetic potential and Indian medicinal plants. J. Herb. Med. Toxicol., 2005, 2(1), 45-50.
Najafian, M.; Ebrahim-Habibi, A.; Hezareh, N.; Yaghmaei, P.; Parivar, K.; Larijani, B. Trans-chalcone: a novel small molecule inhibitor of mammalian alpha-amylase. Mol. Biol. Rep., 2011, 38(3), 1617-1620.
[] [PMID: 20857221]
Amutha, M.; Lalitha, P. Screening of Kedrostis foetidissima (Jacq.) Cogn. extracts for α-amylase inhibition. Int. J. Interdiscipl. Res. Innov., 2015, 3(4), 106-110.
Nirmala, J.; Pandian, R. Study of anti-diabetic activity of Kedrostis feoditissima (Jacq.) Cogn. Int. J. Curr. Res. Acad. Rev., 2015, 3(7), 50-55.
Kim, S.D.; Nho, H.J. Isolation and characterization of α-glucosidase inhibitor from the fungus Ganoderma lucidum. J. Microbiol., 2004, 42(3), 223-227.
[PMID: 15459652]
Pavithra, K.; Vadivukkarasi, S. Evaluation of free radical scavenging activity of various extracts of leaves from Kedrostis foetidissima (Jacq.) Cogn. Food Sci. Hum. Wellness, 2015, 4(2), 42-46.
Kalaisezhiyen, P.; Sathibabu Uddandrao, V.V.; Saravanan, G.; Sasikumar, V. Therapeutic potentiality of Kedrostis foetidissima (Jacq.) Cogn., leaf extracts on free radicals induced oxidative damage in the biological system. Oxid. Antioxid. Med. Sci., 2016, 6(1), 1-5.
Amutha, M.; Lalitha, P. Evaluation of anti oxidant activities of stem and leaf extracts of Kedrostis foetidissima (Jacq) Cogn. Int. J. Res. Pharm. Sci., 2015, 5(1), 28-34.
Gopi, G.; Elumalai, A.; Jayasri, P. In vitro antioxidant activity of Kedrostis foetidissima (Jacq) Cogn. Res. J. Pharma. Phytochem., 2012, 4(4), 209-211.
Jagadeeswari, M.; Hemashenpagam, N. In vitro antioxidant and anti-inflammatory potential of Kedrostis foetidissima (Jacq) Cogn. leaf extracts. J. Pharma Res., 2019, 8(5), 360-365.
Baskaran, K.; Suruthi, B. Anti-anemic activity of ethanolic leaf extract of Kedrostis foetidissima in phenylhydrazine induced anemic rats. Schol. Acad. J. Biosci., 2016, 4(8), 681-683.
Saravanan, V.S.; Manokaran, S. Anti-anaemic activity of some plants in Cucurbitaceae on phenylhydrazine-induced anaemic rats. Thai J. Pharmaceut. Sci., 2012, 36(4), 150-154.
Amutha, M.; Lalitha, P. Evaluation of wound healing activity of leaf and stem extract of Kedrostis foetidissima (Jacq.) Cogn. Res. J. Pharm. Biol. Chem. Sci., 2013, 4(2), 446.
Choene, M.; Motadi, L.R. Anti-proliferative effects of the methanolic extract of Kedrostis foetidissima in breast cancer cell lines. Mol. Biol., 2012, 1(2), 1-5.
Lesetja, R.M. Induction of apoptosis in breast cancer cells using Kedrostis foetidissima. Cancer Res., 2013, 73(8), 2251.
Sivaprakash, V. Antidiarrhoeal activity of Kedrostis foetidissima leaf extract on experimentally induced diarrhoea in mice., 2016.
Priyavardhini, S.; Gowri, S.S.; Vasantha, K.; Umadevi, M. Antibacterial activity of stem and leaf extract ofKedrostis foetidissima (Jacq.) Cogn. Anc. Sci. Life, 2008, 28(2), 10-11.
[PMID: 22557304]
Elavazhagan, T.; Balakrishnan, V. Antibacterial activity of Kedrostis foetidissima (Jacq.) Cogn. Int. J. Curr. Microbiol. Appl. Sci., 2013, 2(4), 104-107.
Priyavardhini, S.; Vasantha, K.; Tresina Soris, P.; Mohan, V.R. Antifungal activity of Kedrostis foetidissima (Jacq.) Cogn. Int. J. Pharm. Tech. Res., 2012, 4(1), 44-48.
Subramani, V.; Kamaraj, M. Trace metal concentration and antimicrobial efficacy of selective medicinal plants, Southern India. Int. J. Pharm. Chem. Biol. Sci., 2014, 4(1), 182-187.
Otieno, J.N.; Lyaruu, H.V.M.; Hosea, K.M.M. Effect of domestication on bioactivity of medicinal herbs: Case of Tarime District Tanzania. In:Discovery and Innovation; 19 special Edition (1 & 2);. , 2007, pp. 85-91.
Amutha, M.; Lalitha, P. Phytochemical screening and in vitro evaluation of antimicrobial activity of Kedrostis foetidissima extract impregnated face mask. Int. J. Pharma Chem. Res., 2015, 1(4), 165-172.
Xu, H.; Hu, C.; Gong, R.; Chen, Y.; Ren, N.; Xiao, G.; Xie, Q.; Zhang, M.; Liu, Q.; Guo, A.; Chen, H. Evaluation of a novel chimeric β-cell epitope based vaccine against mastitis induced by either Streptococcus agalactiae or S. aureus in mice. Clin. Vaccine Immunol., 2011, 18, 893-900.
[] [PMID: 21508165]
Mekala, P.; Poomathi, K.; Radha, P.; Murugesan, S.; Raja, M.J.; Arivuchelvan, A.; Jagadeeswaran, A. Antibacterial activity of Kedrostis foetidissima (Jacq) Cogn. against pathogenic poultry isolates, Indian journal of field veterinarians 2011, 7(1), 21-23.
Raja, M.J.; Selvasubramanian, S.; Ramesh, S.; Pandiyan, V.; Hariharan, P. Study on explorating the antibacterial potential of Kedrostis foetidissima (Jacq.) Cogn. plant of two different locations and comparing its biological activity against mastitis causing pathogens. Proceedings of 7th Kerala Veterinary Science Congress, Indian Veterinary Association Kerala, 2015.
Muthusamy, J.; Palvannan, R.; Annamalai, M.; Babu, H. Phytochemical analysis and antibacterial activity of Kedrostis foetidissima against bovine mastitis isolated bacterial strains. South Asian J. Biol. Sci., 2014, 4(1), 1-4.
Raja, M.J.; Arivuchelvan, A.; Jagadeeswaran, A. Evaluation of antibacterial activity of Kedrostis foetidissima (Jacq.) Cogn. plant extracts against pathogens causing bovine mastitis. J. Pharma. Phytochem., 2019, 8(1), 452-455.
Mothana, R.A.; Al-Musayeib, N.M.; Al-Ajmi, M.F.; Cos, P.; Maes, L.; Cos, P.; Maes, L. Evaluation of the in vitro antiplasmodial, antileishmanial, and antitrypanosomal activity of medicinal plants used in saudi and yemeni traditional medicine. Evid. Based Complement. Alternat. Med., 2014, 2014905639
[] [PMID: 24963330]
Raja, M.J.; Arivuchelvan, A.; Jagadeeswaran, A.; Sukumar, K.; Sivaseelan, S. Exploration of immunomodulatory and growth promoting potentials of Kedrostis foetidissima (Jacq.) Cogn herb in immunosuppressed broilers. IXVI Annual Conference Proceedings of Indian Society of Veterinary Pharmacology and Toxicology, 2016, p. 79.

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