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Current Organic Synthesis


ISSN (Print): 1570-1794
ISSN (Online): 1875-6271

Research Article

Synthesis of New Piperazine Substituted Chalcone Sulphonamides as Antibacterial Agents

Author(s): Yan-Ling Tang, Yong-Kun Li, Min-Xin Li, Hui Gao*, Xiao-Bi Yang and Ze-Wei Mao*

Volume 17 , Issue 2 , 2020

Page: [136 - 143] Pages: 8

DOI: 10.2174/1570179417666191227115207

Price: $65


Background: Infection is a global threat to human health, and there is an urgent need to develop new effective antibacterial drugs to treat bacterial infections.

Objective: To study the antibacterial activity of piperazine substituted chalcone sulphonamides.

Materials and Methods: A series of novel piperazine substituted chalcone sulphonamides have been prepared, and in vitro antibacterial activity against Staphylococcus aureus, Bacillus subtilis and Escherichia coli strains were evaluated.

Results: The results showed that derivatives 6a, 6c and 6h displayed good antibacterial activity against Bacillus subtilis with MIC values of 4.0-8.0 mg/mL.

Conclusion: Piperazine substituted chalcone sulphonamides may be used as potential antibacterial agents.

Keywords: Chalcone, sulphonamide, antibacterial activity, MIC, piperazine, Staphylococcus aureus.

Graphical Abstract
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