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Current Medicinal Chemistry


ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

The 2-Chlorotrityl Resin a Worthy Addition to the Medicinal Chemists Toolbox

Author(s): William J. Hoekstra

Volume 8 , Issue 6 , 2001

Page: [715 - 719] Pages: 5

DOI: 10.2174/0929867013373192

Price: $65


The polystyrene-based 2-chlorotrityl resin was originally used in the synthesis of peptides using an Fmoc-amino acid(slash)carboxyl-linked protocol. While traditionally employed to prepare a number of biologically active peptides, the resin has received increasing attention as a support for the synthesis of pseudopeptide and non-peptide molecules recently. This review focuses on 2-chlorotrityl resin-supported synthesis of small molecules that collectively display a broad range of biological activities.

Keywords: The 2-Chlorotrityl Resin, Polystyrene-based 2-chlorotrityl resin, Synthesis of peptide, Anti-infective agents, Enzyme inhibitors, Nuclear Receptor Modulators

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