Generic placeholder image

Current Pharmaceutical Design

Editor-in-Chief

ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

Systematic Review Article

The Clinical Utility and Assessment of Renal Biomarkers in Acute Kidney Injury After Abdominal Endovascular Aneurysm Repair. A Systematic Review

Author(s): Georgios Karaolanis, Zachary F. Williams, Chris Bakoyiannis, Dimitrios Hadjis , Mitchell W. Cox and Dimitrios Moris*

Volume 25, Issue 44, 2019

Page: [4695 - 4701] Pages: 7

DOI: 10.2174/1381612825666191209122804

Price: $65

Abstract

The widespread adoption of endovascular aneurysm repair (EVAR) for abdominal aortic aneurysms (AAA) is due to the obvious advantages of the procedure compared to the traditional open repair. However, these advantages have to be weighed against the increased risk of renal dysfunction with EVAR. The evaluation of the perioperative renal function after EVAR has been hampered by the lack of sensitive and specific biochemical markers of acute kidney injury (AKI). The purpose of this study was to summarize all novel renal biomarkers and to evaluate their clinical utility for the assessment of the kidney function after EVAR. A systematic review of the current literature, as the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement guidelines, was performed to identify relevant studies with novel renal biomarkers and EVAR. Pubmed and Scopus databases were systemically searched. Studies reporting on thoracic endovascular aortic repair (TEVAR), case reports, case series, letters to the editor, and systematic reviews were excluded. Neutrophil-Gelatinase-Associated Lipocalin, Cystatin C, Liver-type fatty-acid-binding protein were the most common among the eligible studies while Interleukin-18, Retinol binding protein, N-acetyle-b-D-glucosaminidase and microalbumin have a sparse appearance in the literature. These biomarkers have been assessed in plasma as well as urine samples with each sample material having its own advantages and drawbacks. Which of these biomarkers has the most potential for assessing postoperative renal failure after EVAR, remains to be proved. The few studies presented in the literature show the potential clinical utility of these biomarkers, but larger studies with longer follow-up are required to determine the precise relationship between these biomarkers and postoperative acute kidney injury.

Keywords: Abdominal aortic aneurysm, acute kidney injury, biomarkers, endovascular repair, systematic review, systematic reviews and meta-analyses.

[1]
Pisimisis GT, Khoynezhad A, Bashir K, Kruse MJ, Donayre CE, White RA. Incidence and risk factors of renal dysfunction after thoracic endovascular aortic repair. J Thorac Cardiovasc Surg 2010; 140(6)(Suppl.): S161-7.
[http://dx.doi.org/10.1016/j.jtcvs.2010.10.014] [PMID: 21092786]
[2]
Saratzis AN, Goodyear S, Sur H, Saedon M, Imray C, Mahmood A. Acute kidney injury after endovascular repair of abdominal aortic aneurysm. J Endovasc Ther 2013; 20(3): 315-30.
[http://dx.doi.org/10.1583/12-4104MR2.1] [PMID: 23731304]
[3]
Twine CP, Boyle JR. Renal dysfunction after EVAR: time for a standard definition. J Endovasc Ther 2013; 20(3): 331-3.
[http://dx.doi.org/10.1583/12-4104C.1] [PMID: 23731305]
[4]
Sadat U. Radiographic contrast-media-induced acute kidney injury: pathophysiology and prophylactic strategies. ISRN Radiol 2013; 2013 496438
[http://dx.doi.org/10.5402/2013/496438] [PMID: 24967281]
[5]
Devarajan P. Neutrophil gelatinase-associated lipocalin: a promising biomarker for human acute kidney injury. Biomarkers Med 2010; 4(2): 265-80.
[http://dx.doi.org/10.2217/bmm.10.12] [PMID: 20406069]
[6]
Liberati A, Altman DG, Tetzlaff J, et al. The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: explanation and elaboration. BMJ 2009; 339: b2700.
[http://dx.doi.org/10.1136/bmj.b2700] [PMID: 19622552]
[7]
Devarajan P. Emerging urinary biomarkers in the diagnosis of acute kidney injury. Expert Opin Med Diagn 2008; 2(4): 387-98.
[http://dx.doi.org/10.1517/17530059.2.4.387] [PMID: 19079800]
[8]
Goetz DH, Holmes MA, Borregaard N, Bluhm ME, Raymond KN, Strong RK. The neutrophil lipocalin NGAL is a bacteriostatic agent that interferes with siderophore-mediated iron acquisition. Mol Cell 2002; 10(5): 1033-43.
[http://dx.doi.org/10.1016/S1097-2765(02)00708-6] [PMID: 12453412]
[9]
Kol A, Sukhova GK, Lichtman AH, Libby P. Chlamydial heat shock protein 60 localizes in human atheroma and regulates macrophage tumor necrosis factor-alpha and matrix metalloproteinase expression. Circulation 1998; 98(4): 300-7.
[http://dx.doi.org/10.1161/01.CIR.98.4.300] [PMID: 9711934]
[10]
Mishra J, Mori K, Ma Q, et al. Amelioration of ischemic acute renal injury by neutrophil gelatinase-associated lipocalin. J Am Soc Nephrol 2004; 15(12): 3073-82.
[http://dx.doi.org/10.1097/01.ASN.0000145013.44578.45] [PMID: 15579510]
[11]
Yuen PS, Jo SK, Holly MK, Hu X, Star RA. Ischemic and nephrotoxic acute renal failure are distinguished by their broad transcriptomic responses. Physiol Genomics 2006; 25(3): 375-86.
[http://dx.doi.org/10.1152/physiolgenomics.00223.2005] [PMID: 16507785]
[12]
Devarajan P. Review: neutrophil gelatinase-associated lipocalin: a troponin-like biomarker for human acute kidney injury. Nephrology (Carlton) 2010; 15(4): 419-28.
[http://dx.doi.org/10.1111/j.1440-1797.2010.01317.x] [PMID: 20609093]
[13]
Schrezenmeier EV, Barasch J, Budde K, Westhoff T, Schmidt-Ott KM. Biomarkers in acute kidney injury - pathophysiological basis and clinical performance. Acta Physiol (Oxf) 2017; 219(3): 554-72.
[http://dx.doi.org/10.1111/apha.12764] [PMID: 27474473]
[14]
Karaolanis G, Moris D, Palla VV, Karanikola E, Bakoyiannis C, Georgopoulos S. Neutrophil gelatinase associated lipocalin (NGAL) as a biomarker. Does it apply in abdominal aortic aneurysms? A review of literature. Indian J Surg 2015; 77(Suppl. 3): 1313-7.
[http://dx.doi.org/10.1007/s12262-014-1099-1] [PMID: 27011557]
[15]
Karaolanis G, Katsaros A, Palla VV, et al. Urine NGAL as a biomarker of kidney damage after on- and off-pump coronary artery bypass graft surgery: a prospective pilot study. Hellenic J Cardiol 2015; 56(2): 160-8.
[PMID: 25854446]
[16]
Chang CK, Chuter TA, Niemann CU, et al. Systemic inflammation, coagulopathy, and acute renal insufficiency following endovascular thoracoabdominal aortic aneurysm repair. J Vasc Surg 2009; 49(5): 1140-6.
[http://dx.doi.org/10.1016/j.jvs.2008.11.102] [PMID: 19394543]
[17]
Rampoldi B, Tessarolo S, Giubbilini P, et al. Neutrophil gelatinase-associated lipocalin and acute kidney injury in endovascular aneurysm repair or open aortic repair: a pilot study. Biochem Med (Zagreb) 2018; 28(1)010904
[http://dx.doi.org/10.11613/BM.2018.010904] [PMID: 29472806]
[18]
Noorani A, Sadat U, Rollins KE, et al. Assessment of renal injury in patients undergoing elective EVAR using urinary neutrophil gelatin-associated lipocalin, interleukin 18, and retinol-binding protein. Angiology 2017; 68(6): 547-52.
[http://dx.doi.org/10.1177/0003319716672524] [PMID: 27707982]
[19]
Ueta K, Watanabe M, Iguchi N, et al. Early prediction of acute kidney injury biomarkers after endovascular stent graft repair of aortic aneurysm: a prospective observational study. J Intensive Care 2014; 2: 45.
[http://dx.doi.org/10.1186/s40560-014-0045-4] [PMID: 25960881]
[20]
Kalimeris K, Nikolakopoulos N, Riga M, et al. Mannitol and renal dysfunction after endovascular aortic aneurysm repair procedures: a randomized trial. J Cardiothorac Vasc Anesth 2014; 28(4): 954-9.
[http://dx.doi.org/10.1053/j.jvca.2013.08.009] [PMID: 24332919]
[21]
Lisowska-Myjak B. Serum and urinary biomarkers of acute kidney injury. Blood Purif 2010; 29(4): 357-65.
[http://dx.doi.org/10.1159/000309421] [PMID: 20389065]
[22]
Conti M, Moutereau S, Zater M, et al. Urinary cystatin C as a specific marker of tubular dysfunction. Clin Chem Lab Med 2006; 44(3): 288-91.
[http://dx.doi.org/10.1515/CCLM.2006.050] [PMID: 16519600]
[23]
Pirgakis KM, Makris K, Dalainas I, Lazaris AM, Maltezos CK, Liapis CD. Urinary cystatin C as an early biomarker of acute kidney injury after open and endovascular abdominal aortic aneurysm repair. Ann Vasc Surg 2014; 28(7): 1649-58.
[http://dx.doi.org/10.1016/j.avsg.2014.04.006] [PMID: 24858592]
[24]
Aho PS, Niemi T, Lindgren L, Lepäntalo M. Endovascular vs. open AAA repair: similar effects on renal proximal tubular function. Scand J Surg 2004; 93(1): 52-6.
[http://dx.doi.org/10.1177/145749690409300111] [PMID: 15116821]
[25]
Davey P, Peaston R, Rose JD, Jackson RA, Wyatt MG. Impact on renal function after endovascular aneurysm repair with uncovered supra-renal fixation assessed by serum cystatin C. Eur J Vasc Endovasc Surg 2008; 35(4): 439-45.
[http://dx.doi.org/10.1016/j.ejvs.2007.10.005] [PMID: 18077191]
[26]
Abdelhamid MF, Davies RS, Vohra RK, Adam DJ, Bradbury AW. Assessment of renal function by means of cystatin C following standard and fenestrated endovascular aneurysm repair. Ann Vasc Surg 2013; 27(6): 708-13.
[http://dx.doi.org/10.1016/j.avsg.2012.06.016] [PMID: 23548266]
[27]
Ilic NS, Opacic D, Mutavdzic P, et al. Evaluation of the renal function using serum Cystatin C following open and endovascular aortic aneurysm repair. Vascular 2018; 26(2): 132-41.
[http://dx.doi.org/10.1177/1708538117717348] [PMID: 28835187]
[28]
Tan NS, Shaw NS, Vinckenbosch N, et al. Selective cooperation between fatty acid binding proteins and peroxisome proliferator-activated receptors in regulating transcription. Mol Cell Biol 2002; 22(14): 5114-27.
[http://dx.doi.org/10.1128/MCB.22.14.5114-5127.2002] [PMID: 12077340]
[29]
Chmurzyńska A. The multigene family of fatty acid-binding proteins (FABPs): function, structure and polymorphism. J Appl Genet 2006; 47(1): 39-48.
[http://dx.doi.org/10.1007/BF03194597] [PMID: 16424607]
[30]
Yamamoto T, Noiri E, Ono Y, et al. Renal L-type fatty acid--binding protein in acute ischemic injury. J Am Soc Nephrol 2007; 18(11): 2894-902.
[http://dx.doi.org/10.1681/ASN.2007010097] [PMID: 17942962]
[31]
Obata Y, Kamijo-Ikemori A, Ichikawa D, et al. Clinical usefulness of urinary liver-type fatty-acid-binding protein as a perioperative marker of acute kidney injury in patients undergoing endovascular or open-abdominal aortic aneurysm repair. J Anesth 2016; 30(1): 89-99.
[http://dx.doi.org/10.1007/s00540-015-2095-8] [PMID: 26585768]
[32]
Novick D, Kim S, Kaplanski G, Dinarello CA. Interleukin-18, more than a Th1 cytokine. Semin Immunol 2013; 25(6): 439-48.
[http://dx.doi.org/10.1016/j.smim.2013.10.014] [PMID: 24275602]
[33]
Gauer S, Sichler O, Obermüller N, et al. IL-18 is expressed in the intercalated cell of human kidney. Kidney Int 2007; 72(9): 1081-7.
[http://dx.doi.org/10.1038/sj.ki.5002473] [PMID: 17687255]
[34]
Franke EI, Vanderbrink BA, Hile KL, et al. Renal IL-18 production is macrophage independent during obstructive injury. PLoS One 2012; 7(10)e47417
[http://dx.doi.org/10.1371/journal.pone.0047417] [PMID: 23077611]
[35]
Sadat U, Walsh SR, Norden AG, Gillard JH, Boyle JR. Does oral N-acetylcysteine reduce contrast-induced renal injury in patients with peripheral arterial disease undergoing peripheral angiography? A randomized-controlled study. Angiology 2011; 62(3): 225-30.
[http://dx.doi.org/10.1177/0003319710377078] [PMID: 20682612]
[36]
Lapsley M, Akers K, Norden AG. Sensitive assays for urinary retinol-binding protein and beta-2-glycoprotein-1 based on commercially available standards. Ann Clin Biochem 1998; 35(Pt 1): 115-9.
[http://dx.doi.org/10.1177/000456329803500116] [PMID: 9463749]
[37]
Bäcklund M, Pere P, Lepäntalo M, Lehtola A, Lindgren L. Effect of intra-aortic magnesium on renal function during and after abdominal aortic surgery: a pilot study. Acta Anaesthesiol Scand 2000; 44(5): 605-11.
[http://dx.doi.org/10.1034/j.1399-6576.2000.00520.x] [PMID: 10786750]
[38]
Stather PW, Sidloff DA, Dattani N, Choke E, Bown MJ, Sayers RD. Authors’ reply: systematic review and meta-analysis of the early and late outcomes of open and endovascular repair of abdominal aortic aneurysm (Br J Surg 2013; 100: 863-872). Br J Surg 2013; 100(10): 1397-8.
[http://dx.doi.org/10.1002/bjs.9270] [PMID: 24037583]
[39]
Wald R, Waikar SS, Liangos O, Pereira BJ, Chertow GM, Jaber BL. Acute renal failure after endovascular vs. open repair of abdominal aortic aneurysm. J Vasc Surg 2006; 43(3): 460-6.
[http://dx.doi.org/10.1016/j.jvs.2005.11.053] [PMID: 16520155]
[40]
Walsh SR, Tang TY, Boyle JR. Renal consequences of endovascular abdominal aortic aneurysm repair. J Endovasc Ther 2008; 15(1): 73-82.
[http://dx.doi.org/10.1583/07-2299.1] [PMID: 18254679]
[41]
Schley G, Köberle C, Manuilova E, et al. Comparison of plasma and urine biomarker performance in acute kidney injury. PLoS One 2015; 10(12)e0145042
[http://dx.doi.org/10.1371/journal.pone.0145042] [PMID: 26669323]
[42]
Kuwabara T, Mori K, Mukoyama M, et al. Urinary neutrophil gelatinase-associated lipocalin levels reflect damage to glomeruli, proximal tubules, and distal nephrons. Kidney Int 2009; 75(3): 285-94.
[http://dx.doi.org/10.1038/ki.2008.499] [PMID: 19148153]
[43]
Saratzis AN, Bath MF, Harrison SC, Sayers RD, Bown MJ. Impact of fenestrated endovascular abdominal aortic aneurysm repair on renal function. J Endovasc Ther 2015; 22(6): 889-96.
[http://dx.doi.org/10.1177/1526602815605311] [PMID: 26359438]
[44]
Saratzis A, Bath MF, Harrison S, et al. Long-term renal function after endovascular aneurysm repair. Clin J Am Soc Nephrol 2015; 10 1930e6
[http://dx.doi.org/10.2215/CJN.04870515]

Rights & Permissions Print Cite
© 2024 Bentham Science Publishers | Privacy Policy