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Current Pharmaceutical Design


ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

Review Article

β-amyloid and Oxidative Stress: Perspectives in Drug Development

Author(s): Giuseppe Caruso, Simona F. Spampinato, Vincenzo Cardaci, Filippo Caraci, Maria A. Sortino* and Sara Merlo*

Volume 25 , Issue 45 , 2019

Page: [4771 - 4781] Pages: 11

DOI: 10.2174/1381612825666191209115431

Price: $65


Alzheimer’s Disease (AD) is a slow-developing neurodegenerative disorder in which the main pathogenic role has been assigned to β-amyloid protein (Aβ) that accumulates in extracellular plaques. The mechanism of action of Aβ has been deeply analyzed and several membrane structures have been identified as potential mediators of its effect. The ability of Aβ to modify neuronal activity, receptor expression, signaling pathways, mitochondrial function, and involvement of glial cells have been analyzed. In addition, extensive literature deals with the involvement of oxidative stress in Aβ effects. Herein we focus more specifically on the reciprocal regulation of Aβ, that causes oxidative stress, that favors Aβ aggregation and toxicity and negatively affects the peptide clearance. Analysis of this strict interaction may offer novel opportunities for therapeutic intervention. Both common and new molecules endowed with antioxidant properties deserve attention in this regard.

Keywords: Alzheimer’s disease, reactive oxygen species, reactive nitrogen species, neurodegeneration, antioxidants, carnosine.

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