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Current Topics in Medicinal Chemistry


ISSN (Print): 1568-0266
ISSN (Online): 1873-4294

Review Article

Progress in the Mechanism and Clinical Application of Cilostazol

Author(s): Huilei Zheng, Hua Yang, Danping Gong, Lanxian Mai, Xiaoling Qiu, Lidai Chen, Xiaozhou Su, Ruoqi Wei and Zhiyu Zeng*

Volume 19, Issue 31, 2019

Page: [2919 - 2936] Pages: 18

DOI: 10.2174/1568026619666191122123855

Price: $65


Cilostazol is a unique platelet inhibitor that has been used clinically for more than 20 years. As a phosphodiesterase type III inhibitor, cilostazol is capable of reversible inhibition of platelet aggregation and vasodilation, has antiproliferative effects, and is widely used in the treatment of peripheral arterial disease, cerebrovascular disease, percutaneous coronary intervention, etc. This article briefly reviews the pharmacological mechanisms and clinical application of cilostazol.

Keywords: Cilostazol, Mechanism, Clinical application, Anti-platelet aggregation, Antiplatelet drugs, ADP.

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Cheng, X.; Zhao, S.G.; Lin, W.Z.; Xiao, X.; Chou, K.C. pLoc-mAnimal: predict subcellular localization of animal proteins with both single and multiple sites. Bioinformatics, 2017, 33(22), 3524-3531.
[] [PMID: 29036535]
Cheng, X.; Zhao, S.G.; Xiao, X.; Chou, K.C. iATC-mISF: a multi-label classifier for predicting the classes of anatomical therapeutic chemicals. Bioinformatics, 2017, 33(3), 341-346.
[] [PMID: 28172617]
Qiu, W.R.; Sun, B.Q.; Xiao, X.; Xu, Z.C.; Jia, J.H.; Chou, K.C. iKcr-PseEns: Identify lysine crotonylation sites in histone proteins with pseudo components and ensemble classifier. Genomics, 2018, 110(5), 239-246.
[] [PMID: 29107015]
Chen, W.; Feng, P.; Yang, H.; Ding, H.; Lin, H.; Chou, K.C. iRNA-AI: identifying the adenosine to inosine editing sites in RNA sequences. Oncotarget, 2017, 8(3), 4208-4217.
[] [PMID: 27926534]
Liu, B.; Yang, F.; Chou, K.C. 2L-piRNA: A Two-Layer Ensemble Classifier for Identifying Piwi-Interacting RNAs and Their Function. Mol. Ther. Nucleic Acids, 2017, 7, 267-277.
[] [PMID: 28624202]
Liu, B.; Wang, S.; Long, R.; Chou, K.C. iRSpot-EL: identify recombination spots with an ensemble learning approach. Bioinformatics, 2017, 33(1), 35-41.
[] [PMID: 27531102]
Qiu, W.R.; Sun, B.Q.; Xiao, X.; Xu, D. Chou, K.C. iPhos-PseEvo: identifying human phosphorylated proteins by incorporating evolutionary information into general PseAAC via grey system theory. Mol. Inform., 2017, 36(5-6)
Chou, K.C.; Cheng, X. Xiao, X. pLoc_bal-mHum: Predict subcellular localization of human proteins by PseAAC and quasi-balancing training dataset. Genomics, 2018, 111(6), 1274-1282.
Xiao, X.; Cheng, X.; Chen, G.; Mao, Q.; Chou, K.C. pLoc_bal-mGpos: Predict subcellular localization of Gram-positive bacterial proteins by quasi-balancing training dataset and PseAAC. Genomics, 2019, 111(4), 886-892.
[] [PMID: 29842950]
Xiao, X.; Cheng, X.; Chen, G.; Mao, Q.; Chou, K.C. pLoc_bal-mVirus: predict subcellular localization of multi-label virus proteins by chou’s General PseAAC and IHTS treatment to balance training dataset. Med. Chem., 2019, 15(5), 496-509.
[] [PMID: 30556503]
Cheng, X.; Lin, W.Z.; Xiao, X.; Chou, K.C. pLoc_bal-mAnimal: predict subcellular localization of animal proteins by balancing training dataset and PseAAC. Bioinformatics, 2019, 35(3), 398-406.
[] [PMID: 30010789]
Chou, K.C. Advance in predicting subcellular localization of multi-label proteins and its implication for developing multi-target drugs. Curr. Med. Chem., 2019. [Epub ahead of Print
[ 10.2174/0929867326666190507082559] [PMID: 31060481]
Chou, K.C. An unprecedented revolution in medicinal chemistry driven by the progress of biological science. Curr. Top. Med. Chem., 2017, 17(21), 2337-2358.
[] [PMID: 28413951]

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