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Current Drug Therapy

Editor-in-Chief

ISSN (Print): 1574-8855
ISSN (Online): 2212-3903

Review Article

Traditional Herbal Medicines, Newer Herbs and Other Novel Approaches Integrated in Herbal Medicine for Atopic Dermatitis-A Narrative Review

Author(s): Pravin Kumar*, Dinesh Kumar Sharma and Mahendra Singh Ashawat

Volume 15, Issue 3, 2020

Page: [194 - 208] Pages: 15

DOI: 10.2174/1574885514666191018165209

Price: $65

Abstract

Atopic Dermatitis (AD) is a prolonged reverting skin ailment with characteristically distributed skin lesions. In the previous decades, researchers had shown a marked interest in AD due to its increased prevalence in developed countries. Although different strategies including biological and immune modulators are available for the treatment of AD, each has certain limitations. The researchers had shown considerable interest in the management of AD with herbal medicines. The establishment of herbal drugs for AD might eliminate local as well as systemic adverse effects associated with long term use of corticosteroids and also higher cost of therapy with biological drugs. The present review discusses the traditional East Asian herbal medicines and scientific data related to newer herbal extracts or compositions for the treatment of AD. In vivo animal models and in vitro cell cultures, investigated with herbal medicines to establish a possible role in AD treatment, have also been discussed in the paper. The paper also highlights the role of certain new approaches, i.e. pharmacopuncture, a combination of allopathic and herbal medicines; and novel carriers (liposomes, cubosomes) for herbal drugs on atopic skin. In conclusion, herbal medicines can be a better and safe, complementary and alternative treatment option for AD.

Keywords: Atopic dermatitis, eczema, traditional herbal medicine, pharmacopuncture, liposomes, corticosteroids.

Graphical Abstract
[1]
Kramer ON, Strom MA, Ladizinski B, Lio PA. The history of atopic dermatitis. Clin Dermatol 2017; 35(4): 344-8.
[http://dx.doi.org/10.1016/j.clindermatol.2017.03.005] [PMID: 28709563]
[2]
Leung DYM, Bieber T. Atopic dermatitis. Lancet 2003; 361(9352): 151-60.
[http://dx.doi.org/10.1016/S0140-6736(03)12193-9] [PMID: 12531593]
[3]
Novak N, Bieber T, Leung DY. Immune mechanisms leading to atopic dermatitis. J Allergy Clin Immunol 2003; 112(6): S128-39.
[http://dx.doi.org/10.1016/j.jaci.2003.09.032] [PMID: 14657843]
[4]
Schmid-Grendelmeier P, Simon D, Simon HU, Akdis CA, Wüthrich B. Epidemiology, clinical features, and immunology of the “intrinsic” (non-IgE-mediated) type of atopic dermatitis (constitutional dermatitis). Allergy 2001; 56(9): 841-9.
[http://dx.doi.org/10.1034/j.1398-9995.2001.00144.x] [PMID: 11551248]
[5]
Lin L, Zhou Y, Li H, et al. Polysaccharide extracted from Chinese white wax scale ameliorates 2,4-dinitrochlorobenzene-induced atopic dermatitis-like symptoms in BALB/c mice. Saudi Pharm J 2017; 25(4): 625-32.
[http://dx.doi.org/10.1016/j.jsps.2017.04.035] [PMID: 28579902]
[6]
Wan YY. Multi-tasking of helper T cells. Immunology 2010; 130(2): 166-71.
[http://dx.doi.org/10.1111/j.1365-2567.2010.03289.x] [PMID: 20557575]
[7]
Grewe M, Bruijnzeel-Koomen CA, Schöpf E, et al. A role for Th1 and Th2 cells in the immunopathogenesis of atopic dermatitis. Immunol Today 1998; 19(8): 359-61.
[http://dx.doi.org/10.1016/S0167-5699(98)01285-7] [PMID: 9709503]
[8]
Simpson EL, Bieber T, Guttman-Yassky E, et al. Investigators. Two Phase 3 Trials of Dupilumab versus Placebo in Atopic Dermatitis. N Engl J Med 2016; 375(24): 2335-48.
[http://dx.doi.org/10.1056/NEJMoa1610020] [PMID: 27690741]
[9]
Man G, Hu LZ, Elias PM, Man MQ. Therapeutic benefits of natural ingredients for atopic dermatitis. Chin J Integr Med 2018; 24(4): 308-14.
[http://dx.doi.org/10.1007/s11655-017-2769-1] [PMID: 28861804]
[10]
Proksch E, Fölster-Holst R, Jensen JM. Skin barrier function, epidermal proliferation and differentiation in eczema. J Dermatol Sci 2006; 43(3): 159-69.
[http://dx.doi.org/10.1016/j.jdermsci.2006.06.003] [PMID: 16887338]
[11]
Severity scoring of atopic dermatitis: the SCORAD index. Consensus Report of the European Task Force on Atopic Dermatitis. Dermatology 1993; 186(1): 23-31.
[http://dx.doi.org/10.1159/000247298] [PMID: 8435513]
[12]
Wollenberg A, Barbarot S, Bieber T, et al. European Dermatology Forum (EDF), the European Academy of Dermatology and Venereology (EADV), the European Academy of Allergy and Clinical Immunology (EAACI), the European Task Force on Atopic Dermatitis (ETFAD), European Federation of Allergy and Airways Diseases Patients’ Associations (EFA), the European Society for Dermatology and Psychiatry (ESDaP), the European Society of Pediatric Dermatology (ESPD), Global Allergy and Asthma European Network (GA2LEN) and the European Union of Medical Specialists (UEMS). Consensus-based European guidelines for treatment of atopic eczema (atopic dermatitis) in adults and children: part I. J Eur Acad Dermatol Venereol 2018; 32(5): 657-82.
[http://dx.doi.org/10.1111/jdv.14891] [PMID: 29676534]
[13]
Avci P, Sadasivam M, Gupta A, et al. Animal models of skin disease for drug discovery. Expert Opin Drug Discov 2013; 8(3): 331-55.
[http://dx.doi.org/10.1517/17460441.2013.761202] [PMID: 23293893]
[14]
Lim HS, Ha H, Lee H, Lee JK, Lee MY, Shin HK. Morus alba L. suppresses the development of atopic dermatitis induced by the house dust mite in NC/Nga mice. BMC Complement Altern Med 2014; 14: 139-46.
[http://dx.doi.org/10.1186/1472-6882-14-139] [PMID: 24755250]
[15]
Qi XF, Kim DH, Yoon YS, et al. Bambusae caulis in Liquamen suppresses the expression of thymus and activation-regulated chemokine and macrophage-derived chemokine in human keratinocytes due to antioxidant effect. Evid Based Complement Alternat Med 2012; 2012617494
[http://dx.doi.org/10.1155/2012/617494] [PMID: 21785648]
[16]
Lim HS, Seo CS, Ha H, et al. Effect of Alpinia katsumadai Hayata on house dust mite-induced atopic dermatitis in nc/ngamice. Evid Based Complement Alternat Med 2012; 2012705167
[17]
Lee H, Lee JK, Ha H, Lee MY, Seo CS, Shin HK. Angelicae dahuricae radix inhibits dust mite extract-induced atopic dermatitis-like skin lesions in NC/Nga mice. Evid Based Complement Alternat Med 2012; 2012743075
[http://dx.doi.org/10.1155/2012/743075] [PMID: 22454682]
[18]
Hussain Z, Thu HE, Shuid AN, Kesharwani P, Khan S, Hussain F. Phytotherapeutic potential of natural herbal medicines for the treatment of mild-to-severe atopic dermatitis: A review of human clinical studies. Biomed Pharmacother 2017; 93: 596-608.
[http://dx.doi.org/10.1016/j.biopha.2017.06.087] [PMID: 28686974]
[19]
Hon KL, Ma KC, Wong Y, Leung TF, Fok TF. A survey of traditional Chinese medicine use in children with atopic dermatitis attending a paediatric dermatology clinic. J Dermatolog Treat 2005; 16(3): 154-7.
[http://dx.doi.org/10.1080/09546630510038938] [PMID: 16096181]
[20]
Tan HY, Zhang AL, Chen D, Xue CC, Lenon GB. Chinese herbal medicine for atopic dermatitis: a systematic review. J Am Acad Dermatol 2013; 69(2): 295-304.
[http://dx.doi.org/10.1016/j.jaad.2013.01.019] [PMID: 23759835]
[21]
Liu J, Mo X, Wu D, et al. Efficacy of a Chinese herbal medicine for the treatment of atopic dermatitis: a randomised controlled study. Complement Ther Med 2015; 23(5): 644-51.
[http://dx.doi.org/10.1016/j.ctim.2015.07.006] [PMID: 26365443]
[22]
Hon KL, Leung TF, Ng PC, et al. Efficacy and tolerability of a Chinese herbal medicine concoction for treatment of atopic dermatitis: a randomized, double-blind, placebo-controlled study. Br J Dermatol 2007; 157(2): 357-63.
[http://dx.doi.org/10.1111/j.1365-2133.2007.07941.x] [PMID: 17501956]
[23]
Hui PCL, Wang WY, Kan CW, et al. Microencapsulation of Traditional Chinese Herbs-PentaHerbs extracts and potential application in healthcare textiles. Colloids Surf B Biointerfaces 2013; 111: 156-61.
[http://dx.doi.org/10.1016/j.colsurfb.2013.05.036] [PMID: 23792555]
[24]
Liu KYP, Hu S, Chan BCL, et al. Anti-inflammatory and anti-allergic activities of Pentaherb formula, Moutan Cortex (Danpi) and gallic acid. Molecules 2013; 18(3): 2483-500.
[http://dx.doi.org/10.3390/molecules18032483] [PMID: 23439564]
[25]
Tsang MS, Jiao D, Chan BCL, et al. Anti-Inflammatory activities of Pentaherbs formula, berberine, gallic acid and chlorogenic acid in atopic dermatitis-like skin inflammation. Molecules 2016; 21(4): 519-40.
[http://dx.doi.org/10.3390/molecules21040519] [PMID: 27104513]
[26]
Hon KL, Ip M, Wong CK, Chan BCL, Leung PC, Leung TF. In vitro antimicrobial effects of a novel Pentaherbs concoction for atopic dermatitis. J Dermatolog Treat 2018; 29(3): 235-7.
[http://dx.doi.org/10.1080/09546634.2017.1395804] [PMID: 29098912]
[27]
Cheng HM, Chiang LC, Jan YM, Chen GW, Li TC. The efficacy and safety of a Chinese herbal product (Xiao-Feng-San) for the treatment of refractory atopic dermatitis: a randomized, double-blind, placebo-controlled trial. Int Arch Allergy Immunol 2011; 155(2): 141-8.
[http://dx.doi.org/10.1159/000318861] [PMID: 21196758]
[28]
Fang LW, Cheng CC, Hwang TS, et al. Danggui buxue tang inhibits 2,4-dinitrochlorobenzene: induced atopic dermatitis in mice. Evid Based Complement Alternat Med 2015; 2015672891
[http://dx.doi.org/10.1155/2015/672891] [PMID: 25861366]
[29]
Kong L, Wu J, Lin Y, et al. Bushenyiqi Granule inhibits atopic dermatitis via improving central and skin hypothalamic -pituitary -adrenal axis function. PLoS One 2015; 10: 1-15.
[http://dx.doi.org/10.1371/journal.pone.0126040]
[30]
Makino T, Hamanaka M, Yamashita H, Mizukami H. Effect of bakumijiogan, an herbal formula in traditional Chinese medicine, on atopic dermatitis-like skin lesions induced by mite antigen in NC/Jic mice. Biol Pharm Bull 2008; 31(11): 2108-13.
[http://dx.doi.org/10.1248/bpb.31.2108] [PMID: 18981582]
[31]
Yun Y, Ko Y, Ahn JH, et al. Topical application of Jaungo in atopic dermatitis patients: study protocol for a randomized, controlled trial. Trials 2017; 18(1): 176-83.
[http://dx.doi.org/10.1186/s13063-017-1920-9] [PMID: 28403910]
[32]
Ku JM, Hong SH, Kim SR, et al. The prevention of 2,4-dinitrochlorobenzene-induced inflammation in atopic dermatitis-like skin lesions in BALB/c mice by Jawoongo. BMC Complement Altern Med 2018; 18(1): 215-30.
[http://dx.doi.org/10.1186/s12906-018-2280-z] [PMID: 30005655]
[33]
Hwang JS, Kim JE, Yu YB, Im SH. Modulation of experimental atopic dermatitis by topical application of Gami-Cheongyeul-Sodok-Eum. BMC Complement Altern Med 2013; 13: 312-22.
[http://dx.doi.org/10.1186/1472-6882-13-312] [PMID: 24499290]
[34]
Hwang JS, Kim JE, Kim HT, Yu YB, Im SH. Topical application of Taglisodog-eum inhibits the development of experimental atopic dermatitis. J Ethnopharmacol 2013; 145(2): 536-46.
[http://dx.doi.org/10.1016/j.jep.2012.11.026] [PMID: 23211659]
[35]
Kim WY, Kim HG, Lee HW, et al. A herbal formula, Atofreellage, ameliorates atopic dermatitis-like skin lesions in an NC/Nga mouse model. Molecules 2015; 21(1)E35
[http://dx.doi.org/10.3390/molecules21010035] [PMID: 26712731]
[36]
Park BK, Park YC, Jung IC, et al. Gamisasangja-tang suppresses pruritus and atopic skin inflammation in the NC/Nga murine model of atopic dermatitis. J Ethnopharmacol 2015; 165: 54-60.
[http://dx.doi.org/10.1016/j.jep.2015.02.040] [PMID: 25721805]
[37]
Kim SR, Choi HS, Seo HS, et al. Oral administration of herbal mixture extract inhibits 2,4-dinitrochlorobenzene-induced atopic dermatitis in BALB/c mice. Mediators Inflamm 2014; 2014319438
[http://dx.doi.org/10.1155/2014/319438] [PMID: 25132731]
[38]
Kim SR, Choi HS, Seo HS, Choi YK, Shin YC, Ko SG. Topical application of herbal mixture extract inhibits ovalbumin- or 2,4-dinitrochlorobenzene-induced atopic dermatitis. Evid Based Complement Alternat Med 2012; 2012545497
[http://dx.doi.org/10.1155/2012/545497] [PMID: 23304205]
[39]
Jeong SJ, Lim HS, Seo CS, et al. Anti-inflammatory actions of herbal formula Gyejibokryeong-hwan regulated by inhibiting chemokine production and STAT1 activation in HaCaT cells. Biol Pharm Bull 2015; 38(3): 425-34.
[http://dx.doi.org/10.1248/bpb.b14-00660] [PMID: 25757924]
[40]
Na HJ, Shin HY, Kim NH, et al. Regulatory effects of cytokine production in atopic allergic reaction by gammi-danguieumja. Inflammation 2004; 28(5): 291-8.
[http://dx.doi.org/10.1007/s10753-004-6053-0] [PMID: 16134003]
[41]
Park KI, Kim DG, Yoo JM, Ma JY. The herbal medicine KIOM-MA128 inhibits the antigen/IgE-mediated allergic response in vitro and in vivo. Molecules 2016; 21(8): 1-11.
[http://dx.doi.org/10.3390/molecules21081015] [PMID: 27527133]
[42]
Shimizu T. Efficacy of kampo medicine in treating atopic dermatitis: an overview. Evid Based Complement Alternat Med 2013; 2013260235
[http://dx.doi.org/10.1155/2013/260235] [PMID: 24639879]
[43]
Kobayashi H, Ishii M, Takeuchi S, et al. Efficacy and safety of a traditional herbal medicine, Hochu-ekki-to in the long-term management of Kikyo (delicate con-stitution) patients with atopic dermatitis: A 6-month, multi-center, double-blind, randomized, placebo-controlled study. Evid Based Complement Alternat Med 2010; 7: 367-73.
[44]
Mizawa M, Makino T, Hikiami H, Shimada Y, Shimizu T. Effectiveness of keishibukuryogan on chronic-stage lichenification associated with atopic dermatitis. ISRN Dermatol 2012; 2012158598
[http://dx.doi.org/10.5402/2012/158598] [PMID: 23213558]
[45]
Funakushi N, Yamaguchi T, Jiang J, et al. Ameliorating effect of Yokukansan on the development of atopic dermatitis-like lesions and scratching behavior in socially isolated NC/Nga mice. Arch Dermatol Res 2011; 303(9): 659-67.
[http://dx.doi.org/10.1007/s00403-011-1137-9] [PMID: 21365206]
[46]
Choopani R, Mehrbani M, Fekri A, Mehrabani M. Treatment of atopic dermatitis from the perspective of traditional Persian medicine: Presentation of a novel therapeutic approach. J Evid Based Complementary Altern Med 2017; 22(1): 5-11.
[http://dx.doi.org/10.1177/2156587215598610] [PMID: 26260045]
[47]
Mehrbani M, Choopani R, Fekri A, Mehrabani M, Mosaddegh M, Mehrabani M. The efficacy of whey associated with dodder seed extract on moderate-to-severe atopic dermatitis in adults: A randomized, double-blind, placebo-controlled clinical trial. J Ethnopharmacol 2015; 172: 325-32.
[http://dx.doi.org/10.1016/j.jep.2015.07.003] [PMID: 26151244]
[48]
Ha H, Lee H, Seo CS, et al. Artemisia capillaris inhibits atopic dermatitis-like skin lesions in Dermatophagoides farinae-sensitized Nc/Nga mice. BMC Complement Altern Med 2014; 14: 100-10.
[http://dx.doi.org/10.1186/1472-6882-14-100] [PMID: 24624888]
[49]
Yang JH, Yoo JM, Cho WK, Ma JY. Ethanol extract of Sanguisorbae Radix inhibits mast cell degranulation and suppresses 2,4-Dinitrochlorobenzene-induced atopic dermatitis-like skin lesions. Mediators Inflamm 2016; 20162947390
[http://dx.doi.org/10.1155/2016/2947390] [PMID: 27065570]
[50]
Park KH, Jeong MS, Park KJ, Choi YW, Seo SJ, Lee MW. Topical application of Rosa multiflora root extract improves atopic dermatitis-like skin lesions induced by mite antigen in NC/Nga mice. Biol Pharm Bull 2014; 37(1): 178-83.
[http://dx.doi.org/10.1248/bpb.b13-00619] [PMID: 24389494]
[51]
Abbasi S, Kamalinejad M, Babaie D, et al. A new topical treatment of atopic dermatitis in pediatric patients based on Ficus carica L. (Fig): A randomized, placebo-controlled clinical trial. Complement Ther Med 2017; 35: 85-91.
[http://dx.doi.org/10.1016/j.ctim.2017.10.003] [PMID: 29154073]
[52]
Bomstein Y, Rozenblat S. Treatment of atopic dermatitis with KAM-3008, a barrier-based, non-steroidal topical cream. J Dermatolog Treat 2015; 26(5): 426-30.
[http://dx.doi.org/10.3109/09546634.2015.1021238] [PMID: 25893370]
[53]
Lee H, Ha H, Lee JK, Park SJ, Jeong SI, Shin HK. The leaves of Broussonetia kazinoki Siebold inhibit atopic dermatitis-like response on mite allergen-treated Nc/Nga mice. Biomol Ther 2014; 22(5): 438-44.
[http://dx.doi.org/10.4062/biomolther.2014.023] [PMID: 25414775]
[54]
Jung JW, Kim SJ, Ahn EM, et al. Ribes fasciculatum var. chinense attenuated allergic inflammation in vivo and in vitro. Biomol Ther 2014; 22(6): 547-52.
[http://dx.doi.org/10.4062/biomolther.2014.015] [PMID: 25489423]
[55]
Choi JJ, Park B, Kim DH, et al. Blockade of atopic dermatitis-like skin lesions by DA-9102, a natural medicine isolated from Actinidia arguta, in the Mg-deficiency induced dermatitis model of hairless rats. Exp Biol Med 2008; 233(8): 1026-34.
[http://dx.doi.org/10.3181/0801-RM-19] [PMID: 18535171]
[56]
Choi SE, Park KH, Jeong MS, et al. Effect of Alnus japonica extract on a model of atopic dermatitis in NC/Nga mice. J Ethnopharmacol 2011; 136(3): 406-13.
[http://dx.doi.org/10.1016/j.jep.2010.12.024] [PMID: 21184819]
[57]
Choi JK, Oh HM, Lee S, et al. Salvia plebeia suppresses atopic dermatitis-like skin lesions. Am J Chin Med 2014; 42(4): 967-85.
[http://dx.doi.org/10.1142/S0192415X1450061X] [PMID: 25004886]
[58]
Gao CJ, Ding PJ, Yang LL, et al. Oxymatrine sensitizes the HaCaT cells to the IFN-γ pathway and downregulates MDC, ICAM-1, and SOCS1 by activating p38, JNK, and Akt. Inflammation 2018; 41(2): 606-13.
[http://dx.doi.org/10.1007/s10753-017-0716-0] [PMID: 29218605]
[59]
Amagai Y, Katsuta C, Nomura Y, et al. Amelioration of atopic-like skin conditions in NC/Tnd mice by topical application with distilled Alpinia intermedia Gagnep extracts. J Dermatol 2017; 44(11): 1238-47.
[http://dx.doi.org/10.1111/1346-8138.13995] [PMID: 28815692]
[60]
Jung Y, Kim JC, Park NJ, et al. Eupatilin, an activator of PPARα, inhibits the development of oxazolone-induced atopic dermatitis symptoms in Balb/c mice. Biochem Biophys Res Commun 2018; 496(2): 508-14.
[http://dx.doi.org/10.1016/j.bbrc.2018.01.098] [PMID: 29353040]
[61]
Kang YH, Shin HM. Inhibitory effects of Schizandra chinensis extract on atopic dermatitis in NC/Nga mice. Immunopharmacol Immunotoxicol 2012; 34(2): 292-8.
[http://dx.doi.org/10.3109/08923973.2011.602689] [PMID: 21854164]
[62]
Kim MS, Hur YG, Kim WG, et al. Inhibitory effect of Platycodon grandiflorum on T(H)1 and T(H)2 immune responses in a murine model of 2,4-dinitrofluorobenzene-induced atopic dermatitis-like skin lesions. Ann Allergy Asthma Immunol 2011; 106(1): 54-61.
[http://dx.doi.org/10.1016/j.anai.2010.10.020] [PMID: 21195946]
[63]
Lee H, Ha H, Lee JK, et al. The fruits of Cudrania tricuspidata suppress development of atopic dermatitis in NC/Nga mice. Phytother Res 2012; 26(4): 594-9.
[http://dx.doi.org/10.1002/ptr.3577] [PMID: 21972057]
[64]
Lee J, Choi YY, Kim MH, et al. Topical application of Angelica sinensis improves pruritus and skin inflammation in mice with atopic dermatitis-like symptoms. J Med Food 2016; 19(1): 98-105.
[http://dx.doi.org/10.1089/jmf.2015.3489] [PMID: 26305727]
[65]
Matsumoto M, Kotani M, Fujita A, et al. Oral administration of persimmon leaf extract ameliorates skin symptoms and transepidermal water loss in atopic dermatitis model mice, NC/Nga. Br J Dermatol 2002; 146(2): 221-7.
[http://dx.doi.org/10.1046/j.1365-2133.2002.04557.x] [PMID: 11903231]
[66]
Park JG, Yi YS, Han SY, et al. Tabetri™ (Tabebuia avellanedae ethanol extract) ameliorates atopic dermatitis symptoms in mice. Mediators Inflamm 2018; 20189079527
[http://dx.doi.org/10.1155/2018/9079527] [PMID: 29736153]
[67]
Han HM, Kim SJ, Kim JS, et al. Ameliorative effects of Artemisia argyi Folium extract on 2,4dinitrochlorobenzeneinduced atopic dermatitislike lesions in BALB/c mice. Mol Med Rep 2016; 14(4): 3206-14.
[http://dx.doi.org/10.3892/mmr.2016.5657] [PMID: 27571702]
[68]
Yin J, Yoon SH, Ahn HS, Lee MW. Inhibitory activity of allergic contact dermatitis and atopic dermatitis-like skin in BALB/c mouse through oral administration of fermented barks of Alnus sibirica. Molecules 2018; 23(2): 450-61.
[http://dx.doi.org/10.3390/molecules23020450] [PMID: 29463011]
[69]
Nam JH, Jung HW, Chin YW, Yang WM, Bae HS, Kim WK. Spirodela polyrhiza extract modulates the activation of atopic dermatitis-related ion channels, Orai1 and TRPV3, and inhibits mast cell degranulation. Pharm Biol 2017; 55(1): 1324-9.
[http://dx.doi.org/10.1080/13880209.2017.1300819] [PMID: 28290212]
[70]
Hou M, Sun R, Hupe M, et al. Topical apigenin improves epidermal permeability barrier homoeostasis in normal murine skin by divergent mechanisms. Exp Dermatol 2013; 22(3): 210-5.
[http://dx.doi.org/10.1111/exd.12102] [PMID: 23489424]
[71]
Ha H, Lim HS, Lee MY, et al. Luffa cylindrica suppresses development of Dermatophagoides farinae-induced atopic dermatitis-like skin lesions in Nc/Nga mice. Pharm Biol 2015; 53(4): 555-62.
[http://dx.doi.org/10.3109/13880209.2014.932392] [PMID: 25327534]
[72]
Jegal J, Park NJ, Bong SK, Jegal H, Kim SN, Yang MH. Dioscorea quinqueloba ameliorates oxazolone and 2,4-Dinitrochlorobenzene-induced atopic dermatitis symptoms in murine models. Nutrients 2017; 9(12): 1324-35.
[http://dx.doi.org/10.3390/nu9121324] [PMID: 29206209]
[73]
Sohn EH, Jang SA, Lee CH, et al. Effects of korean red ginseng extract for the treatment of atopic dermatitis-like skin lesions in mice. J Ginseng Res 2011; 35(4): 479-86.
[http://dx.doi.org/10.5142/jgr.2011.35.4.479] [PMID: 23717095]
[74]
Park KH, Choi SE, Choi YW, et al. Topical application of two condensed tannins from the root of Rosa multiflora Thunberg for the treatment of atopic dermatitis (AD) in NC/Nga mice. Phytother Res 2011; 25(10): 1564-9.
[http://dx.doi.org/10.1002/ptr.3578] [PMID: 21717518]
[75]
Bae MJ, See HJ, Choi G, Kang CY, Shon DH, Shin HS. Regulatory T cell induced by Poria cocos bark exerts therapeutic effects in murine models of atopic dermatitis and food allergy. Mediators Inflamm 2016; 20163472608
[http://dx.doi.org/10.1155/2016/3472608] [PMID: 27445434]
[76]
Qi XF, Kim DH, Yoon YS, et al. Effects of Bambusae caulis in Liquamen on the development of atopic dermatitis-like skin lesions in hairless mice. J Ethnopharmacol 2009; 123(2): 195-200.
[http://dx.doi.org/10.1016/j.jep.2009.03.020] [PMID: 19429362]
[77]
Jung AR, Ahn SH, Park IS, et al. Douchi (fermented Glycine max Merr.) alleviates atopic dermatitis-like skin lesions in NC/Nga mice by regulation of PKC and IL-4. BMC Complement Altern Med 2016; 16(1): 416-29.
[http://dx.doi.org/10.1186/s12906-016-1394-4] [PMID: 27776525]
[78]
Kim H, Kim JR, Kang H, et al. 7,8,49-Trihydroxyisoflavone attenuates DNCB-induced atopic dermatitis-like symptoms in NC/Nga mice. PLoS One 2014; 9: 1-9.
[79]
Sung YY, Kim DS, Yang WK, et al. Inhibitory effects of Drynaria fortunei extract on house dust mite antigen-induced atopic dermatitis in NC/Nga mice. J Ethnopharmacol 2012; 144(1): 94-100.
[http://dx.doi.org/10.1016/j.jep.2012.08.035] [PMID: 22964469]
[80]
Sung YY, Yang WK, Lee AY, et al. Topical application of an ethanol extract prepared from Illicium verum suppresses atopic dermatitis in NC/Nga mice. J Ethnopharmacol 2012; 144(1): 151-9.
[http://dx.doi.org/10.1016/j.jep.2012.08.042] [PMID: 22971899]
[81]
Sung YY, Lee AY, Kim HK. The Gardenia jasminoides extract and its constituent, geniposide, elicit anti-allergic effects on atopic dermatitis by inhibiting histamine in vitro and in vivo. J Ethnopharmacol 2014; 156: 33-40.
[http://dx.doi.org/10.1016/j.jep.2014.07.060] [PMID: 25153023]
[82]
Sung YY, Yoon T, Jang JY, Park SJ, Jeong GH, Kim HK. Inhibitory effects of Cinnamomum cassia extract on atopic dermatitis-like skin lesions induced by mite antigen in NC/Nga mice. J Ethnopharmacol 2011; 133(2): 621-8.
[http://dx.doi.org/10.1016/j.jep.2010.10.043] [PMID: 21035532]
[83]
Wu G, Li L, Sung GH, et al. Inhibition of 2,4-dinitrofluorobenzene-induced atopic dermatitis by topical application of the butanol extract of Cordyceps bassiana in NC/Nga mice. J Ethnopharmacol 2011; 134(2): 504-9.
[http://dx.doi.org/10.1016/j.jep.2010.12.012] [PMID: 21184821]
[84]
Yang G, Choi CH, Lee K, Lee M, Ham I, Choi HY. Effects of Catalpa ovata stem bark on atopic dermatitis-like skin lesions in NC/Nga mice. J Ethnopharmacol 2013; 145(2): 416-23.
[http://dx.doi.org/10.1016/j.jep.2012.10.015] [PMID: 23195129]
[85]
Yang JH, Lee E, Lee B, et al. Ethanolic extracts of Artemisia apiacea Hance improved atopic dermatitis-like skin lesions in vivo and suppressed TNF-Alpha/IFN-Gamma induced proinflammatory chemokine production in vitro. Nutrients 2018; 10: 806-16.
[http://dx.doi.org/10.3390/nu10070806]
[86]
Cho K, Kang MC, Parveen A, Yumnam S, Kim SY. Anti-inflammatory effect of chloroform fraction of Pyrus ussuriensis Maxim. leaf extract on 2, 4-dinitrochlorobenzene induced atopic dermatitis in Nc/Nga mice. Nutrients 2019; 11(2): 276-88.
[http://dx.doi.org/10.3390/nu11020276] [PMID: 30691219]
[87]
Mechesso AF, Lee SJ, Park NH, et al. Preventive effects of a novel herbal mixture on atopic dermatitis-like skin lesions in BALB/C mice. BMC Complement Altern Med 2019; 19(1): 25-38.
[http://dx.doi.org/10.1186/s12906-018-2426-z] [PMID: 30658631]
[88]
Kwon TK, Kim JC. In vitro skin permeation and anti-atopic efficacy of lipid nanocarriers containing water soluble extracts of Houttuynia cordata. Drug Dev Ind Pharm 2014; 40(10): 1350-7.
[http://dx.doi.org/10.3109/03639045.2013.819883] [PMID: 23886304]
[89]
Jung DL, Lee SD, Choi IH, Na HS, Hong SU. Effects of electroacupuncture on capsaicin-induced model of atopic dermatitis in rats. J Dermatol Sci 2014; 74(1): 23-30.
[http://dx.doi.org/10.1016/j.jdermsci.2013.11.015] [PMID: 24418195]
[90]
Kim MC, Lee CH, Yook TH. Effects of anti-inflammatory and Rehmanniae radix pharmacopuncture on atopic dermatitis in NC/Nga mice. J Acupunct Meridian Stud 2013; 6(2): 98-109.
[http://dx.doi.org/10.1016/j.jams.2012.10.007] [PMID: 23591005]
[91]
Li C, Kim JH, Ji BU, et al. Inhibitory effects of Ganoderma lucidum pharmacopuncture on atopic dermatitis induced by capsaicin in rats. J Dermatol Sci 2015; 80(3): 212-4.
[http://dx.doi.org/10.1016/j.jdermsci.2015.09.010] [PMID: 26472201]
[92]
Kim JH, Kim H. Combination treatment with herbal medicines and Western medicines in atopic dermatitis: Benefits and considerations. Chin J Integr Med 2016; 22(5): 323-7.
[http://dx.doi.org/10.1007/s11655-016-2099-0] [PMID: 27022728]
[93]
Ernst E. Adverse effects of herbal drugs in dermatology. Br J Dermatol 2000; 143(5): 923-9.
[http://dx.doi.org/10.1046/j.1365-2133.2000.03822.x] [PMID: 11069498]
[94]
Koo J, Arain S. Traditional Chinese medicine for the treatment of dermatologic disorders. Arch Dermatol 1998; 134(11): 1388-93.
[http://dx.doi.org/10.1001/archderm.134.11.1388] [PMID: 9828872]

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