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Current Pharmaceutical Design


ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

Review Article

Role of the Endocannabinoidome in Human and Mouse Atherosclerosis

Author(s): Fabiana Piscitelli and Cristoforo Silvestri*

Volume 25, Issue 29, 2019

Page: [3147 - 3164] Pages: 18

DOI: 10.2174/1381612825666190826162735

Price: $65


The Endocannabinoid (eCB) system and its role in many physiological and pathological conditions is well described and accepted, and includes cardiovascular disorders. However, the eCB system has been expanded to an “-ome”; the endocannabinoidome (eCBome) that includes endocannabinoid-related mediators, their protein targets and metabolic enzymes, many of which significantly impact upon cardiometabolic health. These recent discoveries are here summarized with a special focus on their potential involvement in atherosclerosis. We described the role of classical components of the eCB system (eCBs, CB1 and CB2 receptors) and eCB-related lipids, their regulatory enzymes and molecular targets in atherosclerosis. Furthermore, since increasing evidence points to significant cross-talk between the eCBome and the gut microbiome and the gut microbiome and atherosclerosis, we explore the possibility that a gut microbiome - eCBome axis has potential implications in atherosclerosis.

Keywords: Endocannabinoids, cannabinoid receptors, cardiovascular, atherogenesis, gut microbiome, atherosclerosis.

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