Generic placeholder image

Current Biochemical Engineering (Discontinued)


ISSN (Print): 2212-7119
ISSN (Online): 2212-7127

Review Article

Umbelliferone Loaded Nanocarriers for Healthcare Applications

Author(s): Deepika Singh * and Mahfoozur Rahman

Volume 6 , Issue 1 , 2020

Page: [25 - 33] Pages: 9

DOI: 10.2174/2212711906666190730100144


Background: Nanotechnology brings innovation in the healthcare sector and revolutionized the therapeutic domain in recent years. It provides better health facilities and bring advancement in the field of science and technology. Nanocarriers are extremely small structure and involve synthesis, designing, application of medicament in the size range of 1-100 nm. Nanocarriers are especially explored for their chemical, physical and biological activity. Good understanding of all these properties is necessary to increase the therapeutic application of nanocarriers in different fields, by abating the hazards to creatures and the environment. The goal of this article is to review the developed nanocarriers of Umbelliferone from the viewpoints of research trend, synthesis, targeting mechanism, its clinical applications and future perspective.

Methods: A wide variety of nanocarriers system of umbelliferone have been developed, such as nanoshell, nanowire, nanoparticles, solid lipid nanostructure, dendrimers, nanoemulsion, nanosponges, etc. Nanosystem of umbelliferone is prepared by two approaches i.e. top-up and bottom down method, as well as their potential application in several areas, is presented in this paper.

Results: Umbelliferone, a 7-hydroxycoumarin is widely available Rutaceae and Apiaceae families and termed as a therapeutic active agent. It is a derivative of coumarin and contain a heterocyclic ring with the improved biological property. In the literature survey, antifungal, antibacterial, antihyperglycaemic, anti-cancer, anti-diabetic, anti-arthritic, antioxidant and anti-inflammatory property are reported. Nanocarriers encapsulated umbelliferone have been recommended and explored to treat various types of diseases.

Conclusion: This article upsurges the understanding of the nano-based delivery system of drug Umbelliferone in the field of biomedical application along with the safety concerns. A future perspective on the fabrication of nanocarriers of umbelliferone, scaling up technique, therapeutic efficacy and environmental protection is presented in the review. This advocates that numerous possible application of this drug for the future works are available for the commercialization.

Keywords: Umbelliferone, nanocarriers, healthcare applications, nanotechnology, therapeutic domain, science and technology.

Graphical Abstract
P. Pandey, M. Rahman, P.C. Bhatt, S. Beg, B. Paul, A. Hafeez, F.A. Al-Abbasi, M.S. Nadeem, O. Baothman, F. Anwar, and V. Kumar, "Implication of nano-antioxidant therapy for treatment of hepatocellular carcinoma using PLGA nanoparticles of rutin", Nanomedicine (Lond.), vol. 13, no. 8, pp. 849-870, 2018.
[] [PMID: 29565220]
M.Z. Ahmad, S. Akhter, I. Ahmad, M. Rahman, M. Anwar, G.K. Jain, F.J. Ahmad, and R.K. Khar, "Development of polysaccharide based colon targeted drug delivery system: Design and evaluation of Assam Bora rice starch based matrix tablet", Curr. Drug Deliv., vol. 8, no. 5, pp. 575-581, 2011.
[] [PMID: 21696349]
Z. Durmic, and D. Blache, "Bioactive plants and plant products: Effects on animal function, health and welfare", Anim. Feed Sci. Technol., vol. 176, pp. 150-162, 2012.
S. Mura, D.T. Bui, P. Couvreur, and J. Nicolas, "Lipid prodrug nanocarriers in cancer therapy", J. Control. Release, vol. 208, pp. 25-41, 2015.
[] [PMID: 25617724]
O. Mazimba, "Umbelliferone: Sources, chemistry and bioactivities review", Bull. Fac. Pharm. Cairo Univ., vol. 55, pp. 223-232, 2017.
P.K. Jain, and H. Joshi, "Coumarin: Chemical and pharmacological profile", J. Appl. Pharm. Sci., vol. 2, pp. 236-240, 2012.
R. Singh, B. Singh, S. Singh, N. Kumar, S. Kumar, and S. Arora, "Umbelliferone - An antioxidant isolated from Acacia nilotica (L.) Willd. Ex. Del", Food Chem., vol. 120, pp. 825-830, 2010.
J. Nicolas, S. Mura, D. Brambilla, N. Mackiewicz, and P. Couvreur, "Design, functionalization strategies and biomedical applications of targeted biodegradable/biocompatible polymer-based nanocarriers for drug delivery", Chem. Soc. Rev., vol. 42, no. 3, pp. 1147-1235, 2013.
[] [PMID: 23238558]
M. Rahman, M.Z. Ahmad, I. Kazmi, S. Akhter, M. Afzal, G. Gupta, and V.R. Sinha, "Emergence of nanomedicine as cancer targeted magic bullets: recent development and need to address the toxicity apprehension", Curr. Drug Discov. Technol., vol. 9, no. 4, pp. 319-329, 2012.
[] [PMID: 22725687]
L. Brannon-Peppas, and J.O. Blanchette, "Nanoparticle and targeted systems for cancer therapy", Adv. Drug Deliv. Rev., vol. 64, pp. 206-212, 2012.
[] [PMID: 15350294]
S. Nicolas, M.A. Bolzinger, L.P. Jordheim, Y. Chevalier, H. Fessi, and E. Almouazen, "Polymeric nanocapsules as drug carriers for sustained anticancer activity of calcitriol in breast cancer cells", Int. J. Pharm., vol. 550, no. 1-2, pp. 170-179, 2018.
[] [PMID: 30118832]
M. Yokoyama, T. Okano, Y. Sakurai, H. Ekimoto, C. Shibazaki, and K. Kataoka, "Toxicity and antitumor activity against solid tumors of micelle-forming polymeric anticancer drug and its extremely long circulation in blood", Cancer Res., vol. 51, no. 12, pp. 3229-3236, 1991.
[PMID: 2039998]
P. Agrawal, U. Gupta, and N.K. Jain, "Glycoconjugated peptide dendrimers-based nanoparticulate system for the delivery of chloroquine phosphate", Biomaterials, vol. 28, no. 22, pp. 3349-3359, 2007.
[] [PMID: 17459469]
M. Rahman, V. Kumar, S. Beg, G. Sharma, O.P. Katare, and F. Anwar, "Emergence of liposome as targeted magic bullet for inflammatory disorders: Current state of the art", Artif. Cells Nanomed. Biotechnol., vol. 44, no. 7, pp. 1597-1608, 2016.
[] [PMID: 26758815]
N.B. Barros, V. Migliaccio, V.A. Facundo, P. Ciancaglini, R.G. Stábeli, R. Nicolete, and I. Silva-Jardim, "Liposomal-lupane system as alternative chemotherapy against cutaneous leishmaniasis: Macrophage as target cell", Exp. Parasitol., vol. 135, no. 2, pp. 337-343, 2013.
[] [PMID: 23933281]
J. Ahmad, S. Amin, M. Rahman, R.A. Rub, M. Singhal, M.Z. Ahmad, Z. Rahman, R.T. Addo, F.J. Ahmad, G. Mushtaq, M.A. Kamal, and S. Akhter, "Solid matrix based lipidic nanoparticles in oral cancer chemotherapy: Applications and pharmacokinetics", Curr. Drug Metab., vol. 16, no. 8, pp. 633-644, 2015.
[] [PMID: 26264206]
Y. Zhang, Z. Li, K. Zhang, G. Yang, Z. Wang, J. Zhao, R. Hu, and N. Feng, "Ethyl oleate-containing nanostructured lipid carriers improve oral bioavailability of trans-ferulic acid as compared with conventional solid lipid nanoparticles", Int. J. Pharm., vol. 511, no. 1, pp. 57-64, 2016.
[] [PMID: 27374194]
S. Huo, S. Jin, X. Ma, X. Xue, K. Yang, A. Kumar, P.C. Wang, J. Zhang, Z. Hu, and X.J. Liang, "Ultrasmall gold nanoparticles as carriers for nucleus-based gene therapy due to size-dependent nuclear entry", ACS Nano, vol. 8, no. 6, pp. 5852-5862, 2014.
[] [PMID: 24824865]
S.P. Gubin, Magnetic Nanoparticles, 2009.
K.N. Thakkar, S.S. Mhatre, and R.Y. Parikh, "Biological synthesis of metallic nanoparticles", Nanomedicine (Lond.), vol. 6, no. 2, pp. 257-262, 2010.
[] [PMID: 19616126]
S. Beg, M. Rahman, A. Jain, S. Saini, P. Midoux, C. Pichon, F.J. Ahmad, and S. Akhter, "Nanoporous metal organic frameworks as hybrid polymer-metal composites for drug delivery and biomedical applications", Drug Discov. Today, vol. 22, no. 4, pp. 625-637, 2017.
[] [PMID: 27742533]
S.A. Kalele, A.A. Kundu, S.W. Gosavi, D.N. Deobagkar, D.D. Deobagkar, and S.K. Kulkarni, "Rapid detection of Escherichia coli by using antibody-conjugated silver nanoshells", Small, vol. 2, no. 3, pp. 335-338, 2006.
[] [PMID: 17193045]
T.P. Sari, B. Mann, R. Kumar, R.R.B. Singh, R. Sharma, M. Bhardwaj, and S. Athira, "Preparation and characterization of nanoemulsion encapsulating curcumin", Food Hydrocoll., vol. 43, pp. 540-546, 2015.
D.A. Newfang, G.T. Johnson, and R.D. Harbison, Nanoparticles., 6th ed Hamilt. Hardy’s Ind. Toxicol, 2015.
S. Dadashzadeh, K. Derakhshandeh, and F.H. Shirazi, "9-nitrocamptothecin polymeric nanoparticles: cytotoxicity and pharmacokinetic studies of lactone and total forms of drug in rats", Anticancer Drugs, vol. 19, no. 8, pp. 805-811, 2008.
[] [PMID: 18690092]
S. Chaurasia, P. Chaubey, R.R. Patel, N. Kumar, and B. Mishra, "Curcumin-polymeric nanoparticles against colon-26 tumor-bearing mice: cytotoxicity, pharmacokinetic and anticancer efficacy studies", Drug Dev. Ind. Pharm., vol. 42, no. 5, pp. 694-700, 2016.
[] [PMID: 26165247]
C.Y. Wong, H. Al-Salami, and C.R. Dass, "Potential of insulin nanoparticle formulations for oral delivery and diabetes treatment", J. Control. Release, vol. 264, pp. 247-275, 2017.
[] [PMID: 28887133]
T. Shirasu, H. Koyama, Y. Miura, K. Hoshina, K. Kataoka, and T. Watanabe, "Nanoparticles effectively target rapamycin delivery to sites of experimental aortic aneurysm in rats", PLoS One, vol. 11, no. 6, 2016.e0157813
[] [PMID: 27336852]
J.H. Maeng, D.H. Lee, K.H. Jung, Y.H. Bae, I.S. Park, S. Jeong, Y.S. Jeon, C.K. Shim, W. Kim, J. Kim, J. Lee, Y.M. Lee, J.H. Kim, W.H. Kim, and S.S. Hong, "Multifunctional doxorubicin loaded superparamagnetic iron oxide nanoparticles for chemotherapy and magnetic resonance imaging in liver cancer", Biomaterials, vol. 31, no. 18, pp. 4995-5006, 2010.
[] [PMID: 20347138]
N. Vinzant, J.L. Scholl, C.M. Wu, T. Kindle, R. Koodali, and G.L. Forster, "Iron oxide nanoparticle delivery of peptides to the brain: Reversal of anxiety during drug withdrawal", Front. Neurosci., vol. 11, p. 608, 2017.
[] [PMID: 29163012]
F. Nabavizadeh, H. Fanaei, A. Imani, J. Vahedian, F.A. Amoli, J. Ghorbi, H. Sohanaki, S.M. Mohammadi, and R. Golchoobian, "Evaluation of nanocarrier targeted drug delivery of capecitabine-PAMAM dendrimer complex in a mice colorectal cancer model", Acta Med. Iran., vol. 54, pp. 485-493, 2016.
H. Kulhari, D. Pooja, S. Shrivastava, M. Kuncha, V.G.M. Naidu, V. Bansal, R. Sistla, and D.J. Adams, "Trastuzumab-grafted PAMAM dendrimers for the selective delivery of anticancer drugs to HER2-positive breast cancer", Sci. Rep., vol. 6, p. 23179, 2016.
[] [PMID: 27052896]
Y. Lin, T. Fujimori, N. Kawaguchi, Y. Tsujimoto, M. Nishimi, Z. Dong, H. Katsumi, T. Sakane, and A. Yamamoto, "Polyamidoamine dendrimers as novel potential absorption enhancers for improving the small intestinal absorption of poorly absorbable drugs in rats", J. Control. Release, vol. 149, no. 1, pp. 21-28, 2011.
[] [PMID: 20184931]
C. Valdes, G. Bustos, J.L. Martinez, and C. Laurido, "Antinociceptive antibiotics-loaded into solid lipid nanoparticles of prolonged release: Measuring pharmacological efficiency and time span on chronic monoarthritis rats", PLoS One, vol. 13, no. 4, 2018.e0187473
[] [PMID: 29649262]
K. Vandita, B. Shashi, K.G. Santosh, and K.I. Pal, "Enhanced apoptotic effect of curcumin loaded solid lipid nanoparticles", Mol. Pharm., vol. 9, no. 12, pp. 3411-3421, 2012.
[] [PMID: 23127155]
B.L. Fay, J.R. Melamed, and E.S. Day, "Nanoshell-mediated photothermal therapy can enhance chemotherapy in inflammatory breast cancer cells", Int. J. Nanomedicine, vol. 10, pp. 6931-6941, 2015.
[] [PMID: 26609231]
X. Zhang, Y. Wu, M. Zhang, J. Mao, Y. Wu, Y. Zhang, J. Yao, C. Xu, W. Guo, and B. Yu, "Sodium cholate-enhanced polymeric micelle system for tumor-targeting delivery of paclitaxel", Int. J. Nanomedicine, vol. 12, pp. 8779-8799, 2017.
[] [PMID: 29263668]
A. Al Faraj, A.S. Shaik, E. Ratemi, and R. Halwani, "Combination of drug-conjugated SWCNT nanocarriers for efficient therapy of cancer stem cells in a breast cancer animal model", J. Control. Release, vol. 225, pp. 240-251, 2016.
[] [PMID: 26827662]
N.V. Shah, A.K. Seth, R. Balaraman, C.J. Aundhia, R.A. Maheshwari, and G.R. Parmar, "Nanostructured lipid carriers for oral bioavailability enhancement of raloxifene: Design and in vivo study", J. Adv. Res., vol. 7, no. 3, pp. 423-434, 2016.
[] [PMID: 27222747]
K. Wojtowicz, "The effect of 4-hydroxycoumarin and umbelliferone on DPPC bilayers. Ultrasound Study", Eur. Phys. J. Spec. Top., vol. 154, pp. 285-288, 2008.
I. Lacatusu, N. Badea, A. Murariu, O. Oprea, D. Bojin, and A. Meghea, "Antioxidant activity of solid lipid nanoparticles loaded with umbelliferone", Soft Mater., vol. 11, pp. 75-84, 2013.
P.A. Ittadwar, and P.K. Puranik, "Novel umbelliferone phytosomes: Development and optimization using experimental design approach and evaluation of photo-protective and antioxidant activity", Int. J. Pharm. Pharm. Sci., vol. 9, pp. 218-228, 2016.
F. Jia, Y. Wang, H. Wang, Q. Jin, T. Cai, Y. Chen, and J. Ji, "Light cross-linkable and pH de-cross-linkable drug nanocarriers for intracellular drug delivery", Polym. Chem., vol. 11, pp. 2069-2075, 2015.
V. Kumar, P.C. Bhatt, M. Rahman, G. Kaithwas, H. Choudhry, F.A. Al-Abbasi, F. Anwar, and A. Verma, "Fabrication, optimization, and characterization of umbelliferone β-D-galactopyranoside-loaded PLGA nanoparticles in treatment of hepatocellular carcinoma: in vitro and in vivo studies", Int. J. Nanomedicine, vol. 12, pp. 6747-6758, 2017.
[] [PMID: 28932118]

© 2022 Bentham Science Publishers | Privacy Policy