TBAF-Assisted Palladium-Catalyzed Suzuki Reaction in Water Under the Ligand and Base-Free Conditions

Author(s): Xiang-Mei Wu, Yong-Bing Gu.

Journal Name: Letters in Organic Chemistry

Volume 9 , Issue 6 , 2012

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Abstract:

Tetrabutyl ammonium fluoride (abbreviated as TBAF)-assisted palladium-catalyzed Suzuki reaction in neat water has been demonstrated under the ligand and base-free conditions. The cross-coupling of aryl or heteroaryl bromides with arylboronic acids generated the corresponding products in good to excellent yields in the presence of low concentration of palladium acetate in combination with TBAF under air.

Keywords: Arylboronic acid, palladium, suzuki reaction, TBAF, water, N-heterocyclic carbenes, arylimines, ary(heteroaryl)oximes, Suzuki reaction, triphenylphosphine

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Article Details

VOLUME: 9
ISSUE: 6
Year: 2012
Page: [396 - 400]
Pages: 5
DOI: 10.2174/157017812801322408
Price: $65

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