The novel bifunctional compounds L1 and L2 carrying cluster glucosides as ligands for brain targeting
liposomes were synthesized. 2-phenyl-1,3-dioxan-5-ol (8) and tetra-antennary alcohol (13) were used as the core scaffold
to attach cholesterol derivatives by a triethylene glycol chain, while their remaining branches were linked with two or
three benzylglucosides, which would be debenzvlated later to produce di-antennary glucosides L1 and tri-antennary glucosides
ligand L2. This design provided an effective entry for the synthesized bifunctional compounds to cross blood
brain barrier (BBB).
Keywords: Brain target, cholesterylated glucosides, GLUT1 transporter, liposome ligand, synthesis, blood-brain barrier, Liposome-drug, glucose, bi-functional, water-organic
Rights & PermissionsPrintExport