Highly Efficient One Step Synthesis of Primary Amines from B-Chlorodialkylboranes

Author(s): Sanjay V. Malhotra, Herbert C. Brown.

Journal Name: Letters in Organic Chemistry

Volume 9 , Issue 6 , 2012

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Abstract:

A convenient and simple method for synthesis of primary amines has been developed by direct amination of B- Chlorodialkylboranes. This general procedure has been applied to synthesize acyclic, cyclic, hindered and chiral amines in very high yields using both hydroxylamine-O-sulfonic acid and monochloroamine as reagents.

Keywords: Amination, B-Chlorodialkylboranes, chiral amine, organoborane, hydroxy-lamine-O-sulfonic, nitrogen, alkyl group, methyldialkylborane, chlorodialkylborane, water

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Article Details

VOLUME: 9
ISSUE: 6
Year: 2012
Page: [383 - 385]
Pages: 3
DOI: 10.2174/157017812801322453

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