Current Alzheimer Research

Debomoy K. Lahiri  
Department of Psychiatry, Indiana University School of Medicine
Neuroscience Research Center
Indianapolis, IN 46202


The Minority Aging Research Study: Ongoing Efforts to Obtain Brain Donation in African Americans without Dementia

Author(s): Lisa L. Barnes, Raj C. Shah, Neelum T. Aggarwal, David A. Bennett, Julie A. Schneider.


The Minority Aging Research Study (MARS) is a longitudinal, epidemiologic cohort study of decline in cognitive function and risk of Alzheimer’s disease (AD) in older African Americans, with brain donation after death added as an optional component for those willing to consider organ donation. In this manuscript, we first summarize the study design and methods of MARS. We then provide details of ongoing efforts to achieve neuropathologic data on over 100 African Americans participating in MARS and in three other clinical-pathologic cohort studies at Rush University Medical Center. The results examine strategies for recruiting and consenting African Americans without dementia; 2) efforts to maintain high rates of follow-up participation; 3) strategies for achieving high rates of agreement to brain donation; and 4) the methodology of obtaining rapid brain autopsy at death. The implications of these efforts are discussed.

Keywords: Neuropathology, African American, aging, epidemiologic studies, longitudinal, cognitive impairment, neurofibrillary tangles

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Article Details

Year: 2012
Page: [734 - 745]
Pages: 12
DOI: 10.2174/156720512801322627
Price: $58