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Current Alzheimer Research
ISSN (Print): 1567-2050
ISSN (Online): 1875-5828
VOLUME: 9
ISSUE: 6
DOI: 10.2174/156720512801322591      Price:  $58









University of Kentucky Sanders-Brown Healthy Brain Aging Volunteers: Donor Characteristics, Procedures and Neuropathology

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Author(s): Frederick A. Schmitt, Peter T. Nelson, Erin Abner, Stephen Scheff, Gregory A. Jicha, Charles Smith, Gregory Cooper, Marta Mendiondo, Deborah D. Danner, Linda J. Van Eldik, Allison Caban-Holt, Mark A. Lovell and Richard J. Kryscio
Pages 724-733 (10)
Abstract:
Cognitively intact elderly research volunteers at the University of Kentucky have been recruited, followed longitudinally, and autopsied with extensive neuropathological evaluations since 1989. To date, the cohort has recruited 1,030 individuals with 552 participants being actively followed, 363 deceased, and 273 autopsied. An extensive database has been constructed with continuous updates that include textured clinical, neuropsychological, neuroimaging, and pathological information. The history, demographics, clinical observations, and pathological features of this research cohort are described. We also explain some of the evolving methodologies and the academic contributions that have been made due to this motivated group of older Kentuckians.
Keywords:
Aging, alzheimer’s, autopsy, brain, dementia, lewy bodies, longitudinal, neuropathology, neurocognition, neuritic plaques, neurofibrillary tangles
Affiliation:
Department of Neurology and the Sanders-Brown Center on Aging, 303 Sanders-Brown Building, 800 S. Limestone, University of Kentucky, Lexington, KY 40536-0230.