The Memory and Aging Project is a longitudinal, epidemiologic clinical-pathologic cohort study of common
chronic conditions of aging with an emphasis on decline in cognitive and motor function and risk of Alzheimer’s disease
(AD). In this manuscript, we first summarize the study design and methods. Then, we present data on: 1) the relation of
motor function to cognition, disability, and death; 2) the relation of risk factors to cognitive and motor outcomes, disability
and death; 3) the relation of neuropathologic indices to cognitive outcomes; 4) the relation of risk factors to neuropathologic
indices; and 5) additional study findings. The findings are discussed and contextualized.
Keywords: Dementia, Alzheimer's disease, cognitive function, epidemiology, clinical-pathologic study, Catholic clergy, spinal cord, congestive heart failure
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