Overview and Findings from the Religious Orders Study
David A. Bennett, Julie A. Schneider, Zoe Arvanitakis and Robert S. Wilson
Affiliation: Rush Alzheimer's Disease Center, Rush University Medical Center, 600 S. Paulina, Suite 1028, Chicago, IL 60612, USA.
The Religious Orders Study is a longitudinal clinical-pathologic cohort study of aging and Alzheimer’s disease
(AD). In this manuscript, we summarize the study methods including the study design and describe the clinical evaluation,
assessment of risk factors, collection of ante-mortem biological specimens, brain autopsy and collection of selected postmortem
data. The results: 1) review the relation of neuropathologic indices to clinical diagnoses and cognition proximate
to death; 2) examine the relation of risk factors to clinical outcomes; 3) examine the relation of risk factors to measures of
neuropathology; and 4) summarize additional study findings. We then discuss and contextualize the study findings.
Keywords: Religious Orders Study, Dementia, Alzheimer's Disease, Cognitive Function, Epidemiology, Clinical-pathologic
Study, Neuropathology, Cohort
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