Recent Patents on Cardiovascular Drug Discovery

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Cardiovascular Effects of Green Tea Catechins: Progress and Promise

Author(s): Mohammed A. Islam

Affiliation: LECOM Bradenton School of Pharmacy, 5000 Lakewood Ranch Blvd., Bradenton, FL 34211, USA.

Keywords: Antioxidant, anti-inflammatory, atherosclerosis, EGCG, endothelial dysfunction, green tea catechins, HDL cholesterol, LDL cholesterol, Isoflavone Treatment, GREEN TEA

Abstract:

Recently, there is a growing interest in the cardiovascular beneficial effects of green tea. Epidemiological and clinical studies have suggested that consumption of green tea is inversely associated with the risk of developing cardiovascular diseases. Catechins, the major flavonoid constituents of green tea, exert cardioprotective effects through diverse mechanisms that include reversal of endothelial dysfunctions, decreasing inflammatory biomarkers, and providing antioxidant, antiplatelet and antiproliferative effects. Moreover, dietary consumption of green tea catechins has beneficial effects on blood pressure and lipid parameters. This review will focus on discussing the latest research on the cardioprotective effects of green tea catechins and their underlying molecular mechanisms. Several recent patents pertinent to green tea and cardiovascular health will also be discussed. It is noteworthy that clinical studies involving green tea are fraught with multiple complexity and confounding factors. Therefore, a rigorous assessment of the effects of green tea catechins in well-controlled human trials will be required for better understanding of the effects of green tea in cardiovascular health.

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Article Details

VOLUME: 7
ISSUE: 2
Page: [88 - 99]
Pages: 12
DOI: 10.2174/157489012801227292