3-(4'-Geranyloxy-3'-methoxyphenyl)-2-trans propenoic acid (4'-geranyloxyferulic acid, GOFA) is a secondary
metabolite biosynthetically related to ferulic acid in which a geranyl chain is attached to the phenolic group, extracted in
1966 from Acronychia baueri Schott (Fam. Rutaceae). In the last decade the pharmacological properties of the title compound
began to be characterized, revealing its good activity as anti-inflammatory and dietary feeding cancer chemopreventive
agent. The aim of this review is to examine in detail the recently reported properties of 4'-geranyloxyferulic acid
from a chemical and pharmacological point of view, including the recent acquisition about its mechanism of action.
Keywords: Anti-cancer activity, anti-inflammatory activity, cancer chemoprevention, prenyloxycinnamic acids, rutaceae, geranyl chain, 4'-geranyloxyferulic acid, anti-inflammatory, neuroprotective effects, GOFA
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