Current Drug Targets

Francis J. Castellino
Kleiderer-Pezold Professor of Biochemistry
Director, W.M. Keck Center for Transgene Research
Dean Emeritus, College of Science
230 Raclin-Carmichael Hall, University of Notre Dame
Notre Dame, IN 46556
USA

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Targeting Cancer Stem Cells with Natural Products

Author(s): Joseph Burnett, Bryan Newman and Duxin Sun

Affiliation: Department of Pharmaceutical Sciences, College of Pharmacy, The University of Michigan, Room 2020, 428 Church Street, Ann Arbor, MI 48109-1065, USA.

Abstract:

The cancer stem cell (CSC) hypothesis presents a fundamentally different paradigm for cancer treatment. CSCs reflect a small fraction of tumor initiating cells capable of sustained self-renewal and differentiation to form the heterogeneous tumor bulk. In order to cure cancer, it is necessary to eliminate cancer stem cells in addition to differentiated cancer cells to decrease metastasis, reduce recurrence, and improve patient survival. In this article, we review cancer stem cell signaling pathways, including Wnt, Hedgehog, and Notch, as well as interactions of CSCs with the tumor microenvironment. We also review methods to isolate CSCs and demonstrate therapeutic efficacy of natural products to modulate these signaling pathways for eliminating CSCs.

Keywords: Akt, cancer stem cell, hedgehog, HIF-1α, natural product, NF-κB, notch, Wnt signaling, tumor, metastasis

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Article Details

VOLUME: 13
ISSUE: 8
Page: [1054 - 1064]
Pages: 11
DOI: 10.2174/138945012802009062
Price: $58