Abstract
Poor bioavailability of topically instilled drug is the major concern in the field of ocular drug delivery. Efflux transporters, static and dynamic ocular barriers often possess rate limiting factors for ocular drug therapy. Different formulation strategies like suspension, ointment, gels, nanoparticles, implants, dendrimers and liposomes have been employed in order to improve drug permeation and retention by evading rate limiting factors at the site of absorption. Chemical modification such as prodrug targeting various nutrient transporters (amino acids, peptide and vitamin) has evolved a great deal of interest to improve ocular drug delivery. In this review, we have discussed various prodrug strategies which have been widely applied for enhancing therapeutic efficacy of ophthalmic drugs. The purpose of this review is to provide an update on the utilization of prodrug concept in ocular drug delivery. In addition, this review will highlight ongoing academic and industrial research and development in terms of ocular prodrug design and delivery.
Keywords: Prodrug, transporter, receptor, drug delivery, suspension, ointment, gels, nanoparticles, dendrimers, implants, ophthalmic drugs
Medicinal Chemistry
Title:Prodrug Strategies in Ocular Drug Delivery
Volume: 8 Issue: 4
Author(s): Megha Barot, Mahuya Bagui, Mitan R. Gokulgandhi and Ashim K. Mitra
Affiliation:
Keywords: Prodrug, transporter, receptor, drug delivery, suspension, ointment, gels, nanoparticles, dendrimers, implants, ophthalmic drugs
Abstract: Poor bioavailability of topically instilled drug is the major concern in the field of ocular drug delivery. Efflux transporters, static and dynamic ocular barriers often possess rate limiting factors for ocular drug therapy. Different formulation strategies like suspension, ointment, gels, nanoparticles, implants, dendrimers and liposomes have been employed in order to improve drug permeation and retention by evading rate limiting factors at the site of absorption. Chemical modification such as prodrug targeting various nutrient transporters (amino acids, peptide and vitamin) has evolved a great deal of interest to improve ocular drug delivery. In this review, we have discussed various prodrug strategies which have been widely applied for enhancing therapeutic efficacy of ophthalmic drugs. The purpose of this review is to provide an update on the utilization of prodrug concept in ocular drug delivery. In addition, this review will highlight ongoing academic and industrial research and development in terms of ocular prodrug design and delivery.
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Cite this article as:
Barot Megha, Bagui Mahuya, R. Gokulgandhi Mitan and K. Mitra Ashim, Prodrug Strategies in Ocular Drug Delivery, Medicinal Chemistry 2012; 8 (4) . https://dx.doi.org/10.2174/157340612801216283
DOI https://dx.doi.org/10.2174/157340612801216283 |
Print ISSN 1573-4064 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6638 |
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