Acylhydrazide Schiff Bases: DPPH Radical and Superoxide Anion Scavengers

Author(s): Khalid Mohammed Khan , Muhammad Taha , Farzana Naz , Salman Siddiqui , Sajjad Ali , Fazal Rahim , Shahnaz Perveen , M. Iqbal Choudhary .

Journal Name: Medicinal Chemistry

Volume 8 , Issue 4 , 2012

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Abstract:

Acylhydrazide Schiff bases 1-27 were evaluated for their in vitro DPPH radical and superoxide anion scavenging activity. They showed a varying degree of DPPH radical scavenging activity with IC50 values between 31.25 - 473.59 µM. Compounds 8, 2, and 10 have IC50 values 31.25 ± 1.32, 34.40 ± 0.66, and 37.24 ± 0.4 µM, respectively. Standard npropylgallate showed an IC50 value 30.12 ± 0.27 µM. Acylhydrazides 1-27 exhibited in vitro superoxide anion scavenging activities with IC50 values in the range of 175.6 - 450.89 µM. Results demonstrated that acylhyrazides 8, 2, and 10 have DPPH scavenging activity, comparable to standard n-propyl gallate while acylhyrazides 1-27 were found to be less superoxide anion scavenging active than the standard n-propyl gallate (IC50 = 106.34 ± 1.6 µM).

Keywords: Acylhyrazide Schiff bases, DPPH scavenger, superoxide anion scavenger, antioxidant, chemotherapeutic agents, antifungal, antiproliferative properties, anticonvulsant, analgesic

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Article Details

VOLUME: 8
ISSUE: 4
Year: 2012
Page: [705 - 710]
Pages: 6
DOI: 10.2174/157340612801216111
Price: $58

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