Active Metabolites Resulting from Decarboxylation, Reduction and Ester Hydrolysis of Parent Drugs

Author(s): I. Hartyanszky, H. Kalasz, E. Adeghate, Zs. Gulyas, M. Y. Hasan, K. Tekes, A. Adem, P. Sotonyi.

Journal Name: Current Drug Metabolism

Volume 13 , Issue 6 , 2012


Abstract:

Decarboxylation, reduction and hydrolysis can yield active metabolites from the parent drug. Major therapeutic indications and metabolic routes of these drugs are reviewed.

Changes in the logP values (determined and calculated) from the parent drug to the active metabolite show certain characteristics in comparison to other phase I metabolic alterations. Metabolic decarboxylation of parent drug is commonly associated with increase in lipophilicity. However, in some cases, decarboxylation may cause a reduction in lipophilicity. Ester hydrolysis generally unmasks either the polar carboxylic or hydroxyl group with the outcome of an increase in hydrophilicity. On the contrary, hydrolysis of phosphate ester means a huge increase in the lipophilic character of the drug, as the highly polar phosphate group is removed.

Keywords: Active metabolites, metabolic decarboxylation, metabolic reduction and metabolic hydrolysis, Parent Drugs, Idarubicin, Prontosil, lipophilicity, half-life

Rights & PermissionsPrintExport Cite as


Article Details

VOLUME: 13
ISSUE: 6
Year: 2012
Page: [835 - 862]
Pages: 28
DOI: 10.2174/138920012800840437

Article Metrics

PDF: 46