Pregnancy Disorders and Perinatal Outcomes

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Pregnancy Disorders and Perinatal Outcomes offers readers insights into knowledge related to maternal habits or disorders that could affect fetal development and lead to disability later in childhood ...
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Gestational Diabetes Affects Placental-Fetal Development

Pp. 88-96 (9)

Evemie Dubé, Cathy Vaillancourt, Julie Lafond and Louiza Belkacemi

Abstract

Gestational diabetes mellitus occurs only during pregnancy, and usually disappears shortly after delivery. Although, GDM is a common disorder, its pathophysiology is not well understood. Impaired placental function is probably a contributing factor as the placenta hinders insulin signaling and produce increased levels of cytokines that affect placental transport and metabolism of glucose and lipids. This in turn negatively impacts on fetal growth and development with significantly increased risk of a number of short-and long-term adverse consequences for the fetus, and the most significant of which is a predisposition to the development of metabolic syndrome and Type 2 diabetes. This article will describe placental changes in gestational diabetes related to glucose and lipids following placental insulin and cytokines dysfunction, and subsequent effects on the offspring development.

Keywords:

Diabetes, gestation, glucose, receptors, lipids, insulin, cytokines.

Affiliation:

Department of Sciences Biologiques, Université du Québec à Montréal, Montréal, Québec, Canada, H3C 3P8