New Strategies for Metabolic Support in Cancer
Francesco M. Baccino,
Filippo Rossi Fanelli.
The management of cancer patients is frequently complicated by the occurrence of cachexia, a complex syndrome
characterized by marked depletion of body weight, associated with profound alterations of both nutritional status
and metabolic homeostasis. Progressive wasting of skeletal muscle mass and adipose tissue is a typical feature of cancer
cachexia. This syndrome has a large impact on morbidity and mortality, and significantly affects patients’ quality of life.
On this line, understanding the pathogenic mechanisms of cachexia is of crucial importance to define targeted therapeutic
Many studies have addressed the relevance of nutritional interventions in cancer hosts. In particular, it has been shown
that malnutrition in cancer patients can be delayed when nutritional supplementation is adopted early in the course of the
disease. The preservation of a good nutritional status, in particular when it is achieved concurrently with specific antineoplastic
treatment, will prevent or at least delay the onset of overt cachexia, allowing the use of more aggressive therapeutic
This extended and updated version of our previously published article titled “ Nutritional support in cancer” will review
the most recent and relevant literature, focusing on those options that have shown more promising for the clinical practice.
Keywords: Cancer, cachexia, metabolic support, nutritional support, morbidity, mortality, skeletal muscle mass, pathogenic mechanism, therapeutic regimen, nutritional supplemention
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