Chemoinformatics: Directions Toward Combating Neglected Diseases

Indexed in: Scopus

Low-income populations in developing regions of Africa, Asia and the Americas have been particularly injured by a group of tropical infections denominated neglected diseases. Compared to important ...
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Multivariate Image Analysis Applied to QSAR as a Tool for Mosquitoes Control: Dengue and Yellow Fever

Pp. 154-161 (8)

Matheus P. Freitas, Teodorico C. Ramalho, Elaine F. F. da Cunha and Rodrigo A. Cormanich

Abstract

An image-based QSAR approach, called Multivariate Image Analysis Applied to Quantitative Structure-Activity Relationships (MIA-QSAR) is described as a tool to model the toxicities of a series of organotin compounds against Aedes aegypti and Anopheles stephensi mosquito larvae, vectors of dengue and yellow fever. This methodology may help researchers to discover novel, potent mosquito controllers.

Keywords:

QSAR-2D, MIA-QSAR, dengue and yellow fever.

Affiliation:

Department of Chemistry, Federal University of Lavras, P.O. Box 3037, 37200-000, Lavras, MG, Brazil