Pp. 145-153 (9)
Adriana de Oliveira Gomes, Alessandra Mendonça Teles de Souza, Alice Maria Rolim Bernardino, Helena Carla Castro and Carlos Rangel Rodrigues
Chagas disease (American trypanosomiasis) is one of the most important parasitic diseases
with serious social and economic impacts mainly in Latin America. Therefore Chagas’ disease
treatment is still a challenge, mainly in Brazil, where the only commercially available drug is
benznidazole (Rochagan®). Since 1984, the WHO has recommended the use of crystal violet (gentian
violet) in blood banks in endemic areas to prevent transmission by transfusion.
QSAR-3D, CoMFA, Chaga´s Disease.
Laboratório de Modelagem Molecular e QSAR (ModMolQSAR), Faculdade de Farmácia, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil