Chemoinformatics: Directions Toward Combating Neglected Diseases

Indexed in: Scopus

Low-income populations in developing regions of Africa, Asia and the Americas have been particularly injured by a group of tropical infections denominated neglected diseases. Compared to important ...
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Quantitative Structure Activity Analysis of Leishmanicidal Compounds

Pp. 33-48 (16)

Alicia Ponte-Sucre, Emilia Díaz and Maritza Padrón-Nieves

Abstract

Several techniques have been used to study the mechanisms by which receptors recognize ligands, one of them being quantitative structure activity relationship analysis of compounds. This method facilitates the description of molecular details involved in drug recognition by molecular receptors, as well as the molecular mechanism involved. This technique constitutes an essential tool to investigate chemical, electronic, and structural features affecting the leishmanicidal activity of compounds. However, few studies address this topic in Leishmania. Efforts should be made to stimulate research in this area and thus describe the characteristics of leishmanicidal drugs and their interaction with molecular receptors. The present chapter summarizes progress made recently in quantitative structure activity relationship studies of leishmanicidal compounds in experimental and in vivo scenarios. The review highlights possible critical spots in drug design and discusses the potential activity of compounds against different strains of the parasite as a way to optimize the treatment of leishmaniasis.

Keywords:

QSAR, leishmaniasis, Lipinski's rule.

Affiliation:

Laboratory of Molecular Physiology, Institute of Experimental Medicine, Faculty of Medicine, Universidad Central de Venezuela, Caracas, Venezuela