Major depression is one of the leading causes of disability worldwide since it is often accompanied by high
rates of resistance to treatment. Up to 40% of patients do not remit after two adequate pharmacological tryouts (as
indicated by STAR*D study). Poor efficacy of drugs for treatment-resistant depression (TRD) has prompted investigation
of alternative treatment strategies.
Deep Brain Stimulation (DBS) involves the high-frequency electrical stimulation of stereotaxically implanted electrodes
in certain brain regions. Various target areas have been examined for DBS to modulate cortico-limbic circuits, including
the anterior limb in the internal capsule, the ventral capsule / ventral striatum (VC/VS), the nucleus accumbens (NAc),
and the subgenual cingulate gyrus (SCG, Cg25).
DBS for treatment-resistant depression is showing promising results in the few studies published to date, and could
potentially open new therapeutic opportunities as an effective long-term treatment strategy with low adverse effects for
such a chronic, refractory population.
Keywords: Deep Brain Stimulation, DBS, Treatment-Resistant Depression, TRD, Subgenual Cingulate Gyrus, Nucleus
Accumbens, Ventral Striatum, antidepressant, Neuromodulating, orbitofrontal
Rights & PermissionsPrintExport