Biotechnological Production of Plant Secondary Metabolites

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Modern techniques have been developed to overcome problems associated with the extraction of natural products from plants. These techniques include production of secondary metabolites by ...
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Novel Biomedical Agents from Plants

Pp. 53-66 (14)

Athar Ata

Abstract

Natural product chemistry is playing a key role in providing structural diversity and this feature makes them an important source of lead drug candidates to the drug discovery program. Nearly 50% of the prescribed drugs available on the market are of natural product origin and 25% of these commercially available drugs are of plant origin. Enzymes are responsible for performing several biochemical processes including metabolisms, catabolism, signal transductions, cell development and their growth. Over expression and hyper-activation of enzymes cause several human diseases. With the development of modern techniques in the field of molecular biology and enzymology, over expression and hyper-activation of enzymes in the body can easily be diagnosed that led to understand human diseases at the molecular level. An understanding of diseases at the molecular level resulted in the successful applications of enzyme inhibitors in clinics to treat these diseases. This chapter describes the discovery of novel glutathione S-transferase, acetylcholinesterase and α-glucosidase inhibitors from medicinally important plants and their biomedical applications. Additionally, biotechnological method to produce potent bioactive compounds on a large scale using biosynthetic information has also been proposed.

Keywords:

Natural products, enzyme inhibition, glutathione S-transferase, acetylcholinesterase, α- glucosidase, phytochemistry, biosynthesis, isolation, pharmacophore, bioactivity.

Affiliation:

Department of Chemistry, The University of Winnipeg, 515 Portage Avenue, Winnipeg, MB, Canada R3B 2E9