Utility of DNA Methyltransferase Inhibitors for the Treatment of Myelodysplastic Syndromes

Author(s): Kaoru Tohyama .

Journal Name: Current Pharmaceutical Design

Volume 18 , Issue 22 , 2012

Abstract:

Unprecedented progress continues to be made in the treatment strategies for the myelodysplastic syndromes (MDS). This review provides an introduction to DNA methyltransferase inhibitors. These agents include 5-azacytidine (azacitidine; AZA) and 5-aza-2’- deoxycytidine (decitabine; DAC). In particular, AZA was shown for the first time to significantly prolong the life expectancy of high-risk MDS patients in international multicenter clinical studies. The selection of responders and assessment of the long-term efficacy warrant further study.

Keywords: MDS, DNA hypomethylation, epigenetic therapy, DNA methyltransferase inhibitors, azacitidine, decitabine, long-term efficacy, hematopoietic stem cell disorders, solid tumors, cytotoxic

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Article Details

VOLUME: 18
ISSUE: 22
Year: 2012
Page: [3190 - 3197]
Pages: 8
DOI: 10.2174/1381612811209023190
Price: $58

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