Protein-protein interaction networks play a central role in a large number of cellular processes. Interaction networks
are regulated to a large extent through post-translational modifications. The underlying causes of many diseases are
found in defective protein-protein interactions and the resulting dysregulated signaling. Study and inhibition of proteinprotein
interaction networks are thus crucial to the understanding of physiological and disease processes. Small molecules
so far have been the mainstay as chemical genetic and therapeutic tools. Inherent instability, low plasma half-life and
other characteristics of peptides have so far prevented their widespread use in chemical genetics and therapy. However,
recent developments have removed many of the drawbacks in use of peptides within cells and in organisms; as a consequence,
peptides are poised to take a new leap as a promising class of molecules for use in chemical genetics and therapeutics.
In this article we review recent developments in this area. We discuss methods for developing peptides that bind a
given target. We also explore the use of peptides for targeting to organs and organelles. Due to modular nature of functionalities
within a peptide, different functionalities can be combined in a peptide with relative ease. This characteristic,
combined with biocompatible nature of the entity make future of peptides bright as therapeutic agents.
Keywords: Helix, homing, inhibition, mimetics, peptide, protein-protein interaction, targeting, therapeutics, Protein-protein interaction inhibitors, phagemid genome, repA sequence, multiple cyclic metallopeptide modules
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