Abstract
Mesenchymal stem cells (MSCs) have a great capacity for use in regenerative medicine and other clinical applications. However, one question creating curiosity of their use, is how they are affected by ageing. As we now live within an ageing population, the prevalence of age related disorders is increasing, so it is important to investigate how effectively MSCs from older patients can be expanded and differentiated in vitro before their use in autologous cell transplantation. This paper will look at how ageing effects proliferation potential, differentiation potential and cell surface characterisation of human mesenchymal stem cells.
Keywords: Ageing, characterisation, differentiation, mesenchymal stem cells, proliferation, regenerative medicine, inner cell mass, embryonic stem, adult stem cells, muscle tissue
Current Stem Cell Research & Therapy
Title:The Effects of Ageing on Proliferation Potential, Differentiation Potential and Cell Surface Characterisation of Human Mesenchymal Stem Cells
Volume: 7 Issue: 4
Author(s): Emma Fossett, Wasim S. Khan, Philip Pastides and Adetola B. Adesida
Affiliation:
Keywords: Ageing, characterisation, differentiation, mesenchymal stem cells, proliferation, regenerative medicine, inner cell mass, embryonic stem, adult stem cells, muscle tissue
Abstract: Mesenchymal stem cells (MSCs) have a great capacity for use in regenerative medicine and other clinical applications. However, one question creating curiosity of their use, is how they are affected by ageing. As we now live within an ageing population, the prevalence of age related disorders is increasing, so it is important to investigate how effectively MSCs from older patients can be expanded and differentiated in vitro before their use in autologous cell transplantation. This paper will look at how ageing effects proliferation potential, differentiation potential and cell surface characterisation of human mesenchymal stem cells.
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Cite this article as:
Fossett Emma, S. Khan Wasim, Pastides Philip and B. Adesida Adetola, The Effects of Ageing on Proliferation Potential, Differentiation Potential and Cell Surface Characterisation of Human Mesenchymal Stem Cells, Current Stem Cell Research & Therapy 2012; 7 (4) . https://dx.doi.org/10.2174/157488812800793027
DOI https://dx.doi.org/10.2174/157488812800793027 |
Print ISSN 1574-888X |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-3946 |
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