Substituted Urea Derivatives: A Potent Class of Antidepressant Agents

Author(s): Shahnaz Perveen , Sana Mustafa , Muhammad A. Khan , Ahsana Dar , Khalid M. Khan , Wolfgang Voelter .

Journal Name: Medicinal Chemistry

Volume 8 , Issue 3 , 2012

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A series of fourteen (14) N-nitrophenyl-N'-(alkyl/aryl)urea and symmetrical 1,3-disubstituted urea derivatives were synthesized and evaluated for their antidepressant activity in mice. Among them, N-(4-nitrophenyl)-N'-(1'-phenylethyl)urea (1), demonstrated profound antidepressant property as reflected by significant reduction in the immobility time (89.83%), whereas compounds 2-6 showed activity values between 36 to 59% which were also larger than the standard phenelzine. Compounds 7-9 were less effective in reducing the immobility period of mice 26.20 to 31.01%). This variable magnitude of antidepressant activity appears to be related to the position of the nitro group to the parent molecules 1, 2, and 8. Compound 1 with the nitro group at para position showed to be the most effective antidepressant. However, the activity declined, if the nitro is attached to ortho and meta positions.

Keywords: Amines, Antidepressant, Disubstituted urea derivatives, Isocyanate, Symmetrical urea, Tail suspension test (TST), carbamates, lipoproteinelevating, cholinergic agents

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Article Details

Year: 2012
Page: [330 - 336]
Pages: 7
DOI: 10.2174/157340612800786615
Price: $58

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