Ionizing radiation used for sterilization of drugs may lead to drug degradation and therefore essential element
of the validation process is the choice of optimal conditions for sterilization, i.e. radiation dose and radiation source. This
investigation examines and compares radiostability of derivatives of 1-phenylpropan-1-ol exposed to the same effective
doses of ionizing radiation but emitted from different sources: gamma radiation (60Co) and high energy electrons emitted
by linear electron accelerator. The drugs used in this investigation were chloramphenicol, its ester (chloramphenicol sodium
succinate) and analog (thiamphenicol).
It was found that gamma radiation had a more destructive effect on drugs than high energy electrons. This was apparent
from the change in the color intensity, increase in the concentration of free radicals, the number of radiolysis products and
larger decrease in the drug content. The difference in the power between the two sources of ionizing radiation (1 kGy/h
for 60Co and 10 kGy/s for high energy electrons) could account for that.
Keywords: EPR, radiation sterilization, radiodegradation, radiolytic yield, gamma radiation, electrons, ionizing radiation, chloramphenicol, radiostability, microbiological purity
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