Functional Magnetic Resonance Imaging and Treatment Strategies in Schizophrenia
Susanne Karch, Oliver Pogarell and Christoph Mulert
Affiliation: Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-University Munich, NussbaumstraBe 7, D - 80336 Munich, Germany.
Keywords: fMRI, Schizophrenia, Treatment effects, Neurobiological correlates, "psychopharmacology", neuroimaging studies, parietal brain regions, ventral striatum, numerous studies, "anterior cingulate cortex", ventral striatum, amygdala, atypical antipsychotics, neuroleptics
Neurobiological correlates of various treatment approaches (e.g. psychopharmacology, cognitive behavioural
therapy) have become an important issue in recent neuroimaging studies. In schizophrenia, dysfunctions especially in
frontal and parietal brain regions as well as the ventral striatum have been demonstrated in numerous studies. The review
includes functional MRI studies about neurobiological correlates of treatment effects in schizophrenic patients. Treatmentassociated
changes in brain activity were shown especially in the anterior cingulate cortex, the dorsolateral prefrontal cortex,
the ventral striatum and the amygdala. In addition, the differential effects of various treatment approaches including
different neuroleptics (atypical neuroleptics, typical neuroleptics) as well as cognitive behavioural therapy will be considered
in this review. The influence of functional differences on the differential effect of typical and atypical antipsychotics
on cognitive functions will be discussed.
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