Abstract
The continuing problem of the emergence of multidrug resistance in pathogens has resulted in renewed efforts to identify novel antimicrobials that could be used in clinical settings. Lantibiotics are bacterially produced gene encoded antimicrobial peptides which have been the focus of extensive investigation in recent years because of their broad spectrum of activity. Lantibiotics (lanthionine-containing antibiotics), which have traditionally been regarded as antimicrobials for use in food or veterinary medicine, may provide at least part of the solution to these problems. Lacticin 3147 is a two peptide lantibiotic (consisting of the peptides Ltnα and Ltnβ) which is active at low concentrations against many pathogens. It has been the subject of extensive research, which has generated significant insights into the mechanisms of lacticin 3147 biosynthesis, immunity, structure function relationships and the consequences of molecular bioengineering. The merits of employing lacticin 3147 to control spoilage microbes as well as its potential in the elimination of food, human and veterinary pathogens have also been highlighted. Here we review the knowledge which has been gained with respect to lacticin 3147 since its discovery in 1995.
Keywords: Antimicrobial peptides, bacteriocins, bioengineering, lacticin 3147, lantibiotics, lantibiotic applications, mutagenesis, genera, bioavailability, biostability
Current Protein & Peptide Science
Title:Lacticin 3147 - Biosynthesis, Molecular Analysis, Immunity, Bioengineering and Applications
Volume: 13 Issue: 3
Author(s): Srinivas Suda, Paul D. Cotter, Colin Hill and R. Paul Ross
Affiliation:
Keywords: Antimicrobial peptides, bacteriocins, bioengineering, lacticin 3147, lantibiotics, lantibiotic applications, mutagenesis, genera, bioavailability, biostability
Abstract: The continuing problem of the emergence of multidrug resistance in pathogens has resulted in renewed efforts to identify novel antimicrobials that could be used in clinical settings. Lantibiotics are bacterially produced gene encoded antimicrobial peptides which have been the focus of extensive investigation in recent years because of their broad spectrum of activity. Lantibiotics (lanthionine-containing antibiotics), which have traditionally been regarded as antimicrobials for use in food or veterinary medicine, may provide at least part of the solution to these problems. Lacticin 3147 is a two peptide lantibiotic (consisting of the peptides Ltnα and Ltnβ) which is active at low concentrations against many pathogens. It has been the subject of extensive research, which has generated significant insights into the mechanisms of lacticin 3147 biosynthesis, immunity, structure function relationships and the consequences of molecular bioengineering. The merits of employing lacticin 3147 to control spoilage microbes as well as its potential in the elimination of food, human and veterinary pathogens have also been highlighted. Here we review the knowledge which has been gained with respect to lacticin 3147 since its discovery in 1995.
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Cite this article as:
Suda Srinivas, D. Cotter Paul, Hill Colin and Paul Ross R., Lacticin 3147 - Biosynthesis, Molecular Analysis, Immunity, Bioengineering and Applications, Current Protein & Peptide Science 2012; 13 (3) . https://dx.doi.org/10.2174/138920312800785021
DOI https://dx.doi.org/10.2174/138920312800785021 |
Print ISSN 1389-2037 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5550 |
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