Unusual Course of the Reaction of Lawesson’s Reagent with β-Phosphoryl- β’-carbethoxyhydrazones: First Synthesis of 5-Mercapto-3-(methylthiophosphoryl) pyrazoles

Author(s): Emna Chebil, Soufiane Touil.

Journal Name: Letters in Organic Chemistry

Volume 9 , Issue 5 , 2012

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Abstract:

It is well known that Lawesson’s reagent (LR) reacts with hydrazone derivatives at 80 °C to yield 3-thioxo- 1,2,3-diazaphospholine derivatives. We show, in the present investigation, that the reaction of LR with β- phosphoryl-β’-carbethoxyhydrazones under the same conditions, took an entirely different course and gave a new type of pyrazole derivatives, the 5-mercapto-3-(methylthiophosphoryl)pyrazoles.

Keywords: Hydrazones, Lawesson’s reagent, mercaptopyrazoles, pyrazoles, thiophosphorylpyrazoles, heterocyclic, agrochemistry, anticancer, antiviral, antimicrobial

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Article Details

VOLUME: 9
ISSUE: 5
Year: 2012
Page: [320 - 324]
Pages: 5
DOI: 10.2174/157017812801264764

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