Abstract
The low incidence of cardiovascular disease in countries bordering the Mediterranean basin, where olive oil is the main source of dietary fat, and the negative association between this disease with high density lipoproteins has stimulated interest. This review summarizes the current knowledge gathered from human and animal studies regarding olive oil and high density lipoproteins. Cumulative evidence suggests that high density lipoprotein (HDL) cholesterol, and its main apolipoprotein A1, may be increased by consuming olive oil when compared with carbohydrate and low fat diets in humans. Conflicting results have been found in many studies when olive oil diets were compared with other sources of fat. The role of virgin olive oil minor components on its protective effect has been demonstrated by a growing number of studies although its exact mechanism remains to be elucidated. Dietary amount of olive oil, use of virgin olive oil, cholesterol intake, and physiopathological states such as genetic background, sex, age, obesity or fatty liver are variables that may offset those effects. Further studies in this field in humans and in animal models are warranted due to the complexity of HDL particles.
Keywords: Apolipoprotein, high density lipoprotein, olive oil, cardiovascular risk, obesity, coronary heart disease, hypertension, hypertriglyceridemia, metabolic syndrome
Current Vascular Pharmacology
Title:HDL-Related Mechanisms of Olive Oil Protection in Cardiovascular Disease
Volume: 10 Issue: 4
Author(s): Jose M. Lou-Bonafonte, Montse Fito, Maria-Isabel Covas, Marta Farras and Jesus Osada
Affiliation:
Keywords: Apolipoprotein, high density lipoprotein, olive oil, cardiovascular risk, obesity, coronary heart disease, hypertension, hypertriglyceridemia, metabolic syndrome
Abstract: The low incidence of cardiovascular disease in countries bordering the Mediterranean basin, where olive oil is the main source of dietary fat, and the negative association between this disease with high density lipoproteins has stimulated interest. This review summarizes the current knowledge gathered from human and animal studies regarding olive oil and high density lipoproteins. Cumulative evidence suggests that high density lipoprotein (HDL) cholesterol, and its main apolipoprotein A1, may be increased by consuming olive oil when compared with carbohydrate and low fat diets in humans. Conflicting results have been found in many studies when olive oil diets were compared with other sources of fat. The role of virgin olive oil minor components on its protective effect has been demonstrated by a growing number of studies although its exact mechanism remains to be elucidated. Dietary amount of olive oil, use of virgin olive oil, cholesterol intake, and physiopathological states such as genetic background, sex, age, obesity or fatty liver are variables that may offset those effects. Further studies in this field in humans and in animal models are warranted due to the complexity of HDL particles.
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Cite this article as:
M. Lou-Bonafonte Jose, Fito Montse, Covas Maria-Isabel, Farras Marta and Osada Jesus, HDL-Related Mechanisms of Olive Oil Protection in Cardiovascular Disease, Current Vascular Pharmacology 2012; 10 (4) . https://dx.doi.org/10.2174/157016112800812827
DOI https://dx.doi.org/10.2174/157016112800812827 |
Print ISSN 1570-1611 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6212 |
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