Functional Molecular Imaging In Hepatology

The eBook discusses how the special physiology of the liver must be considered when applying functional molecular imaging in hepatology. The main topics of the eBook include the clinical and ...
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Cerebral Glucose Metabolism in Patients with Liver Cirrhosis and Hepatic Encephalopathy

Pp. 145-152 (8)

Karin Weissenborn and Alan H. Lockwood

Abstract

Hepatic encephalopathy shows very distinct clinical features combining cognitive dysfunction, alterations of consciousness and motor symptoms indicating an alteration of the extrapyramidal and cerebellar motor system and the pyramidal tract. Positron emission tomography studies of the cerebral glucose utilisation in patients with liver cirrhosis and various grades of hepatic encephalopathy show accordingly alterations in distinct brain areas – a decrease of the glucose utilisation especially in the frontal cortex and anterior cingulated gyrus, and an increase in the hippocampus, basal ganglia and cerebellum. These alterations in cerebral glucose utilisation correlate significantly with psychometric test results and brain metabolite alterations as measured by magnetic resonance spectroscopy.

Keywords:

Hepatic encephalopathy; [18F]fluoro-deoxy-D-glucose; Positron emission tomography; Magnetic resonance spectroscopy; Attention system.

Affiliation:

Department of Neurology, Hannover Medical School, Hannover, Germany