Functional Molecular Imaging In Hepatology

The eBook discusses how the special physiology of the liver must be considered when applying functional molecular imaging in hepatology. The main topics of the eBook include the clinical and ...
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Neuroendocrine Tumours with Secondary Liver Lesions

Pp. 120-128 (9)

Valentina Ambrosini, Davide Campana, Paola Tommassetti and Stefano Fanti

Abstract

Secondary liver lesions are frequently encountered in neuroendocrine tumours (NET) of the gastro-entero-pancreatic tract. Although conventional morphologic imaging modalities and somatostatin receptor scintigraphy (SRS) have been extensively used in past decades, with the advent of PET/CT, new diagnostic procedures are currently available with the employment of different beta emitting tracers. In fact NET can be easily visualised on PET scans using an array of both metabolic and receptor-based tracers. 3,4-dihydroxy-6-[18F]fluoro-L-phenylalanine (18F-DOPA) and 68Ga-DOTApeptides (DOTA-TOC, DOTA-NOC, DOTA-TATE) are very promising to image well-differentiated NET and were reported to be superior to other imaging modalities (CT, SRS). On the contrary, the role of 18F-FDG is limited in well-differentiated NET, due to their low glucose metabolism and growth rate, while it can still provide valuable information in less differentiated NET or in forms with lower expression of somatostatin receptors.

Keywords:

PET; CT; Neuroendocrine tumours; 18F-FDG; 18F-DOPA; 68Ga-DOTA-peptides

Affiliation:

Nuclear Medicine Unit and Internal Medicine Unit, S. Orsola-Malpighi University Hospital Bologna, Italy