Traditionally, drug therapy for pediatric ischemic stroke has been extrapolated from adult guidelines and studies.
This approach is not optimal due to important differences between adult and pediatric stroke (e.g. etiologies, maturation
changes in hemostasis). Research in pediatric stroke is increasing, and pediatric specific management guidelines have
recently become available. This manuscript summarizes available drug therapy recommendations for pediatric ischemic
stroke. Both acute management and secondary stroke prevention are discussed, including antiplatelet, anticoagulant, and
thrombolytic drugs. When relevant, recommendations from adult ischemic stroke guidelines and data from pediatric
stroke studies are incorporated.
Keywords: Anticoagulation, pediatric, stroke, thrombolytic, secondary stroke, anticoagulant, antiplatelet, ACUTE MANAGEMENT, evidence-based guidelines, hemostatic systems
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