Pharmacological Therapies for Pediatric and Neonatal ALI/ARDS: An Evidence-Based Review

Daniele      De Luca; Marco      Piastra; Federica      Tosi; Silvia      Pulitano; Aldo      Mancino; Orazio      Genovese; Domenico      Pietrini; Giorgio      Conti

Abstract

Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are life-threating conditions still lacking a definite therapy and carrying a high mortality and morbidity, especially in children and infants. Albeit respiratory assistance and supportive therapies are crucial for ALI/ARDS, many drugs have been proposed to treat such syndromes through various mechanisms of action. On the whole the pharmacological therapy might play an important role in such a complex clinical situation but few evidence based data are available in pediatric and neonatal critical care. This review will focus on drugs directly available on the bedside, that is, medicines already administered in the practice or investigated in at least one clinical study. We will value the differences due to patient’s age and the various causes of the syndrome, that may affect the response to the pharmacological therapy. A special attention will be given to the drugs directly deliverable into the lungs, as this strategy allows a total availability to the lung tissue. The experimental background behind each drug will be discussed and then clinical data in neonates and infants will be presented, if available. Data coming from adult critical care and thought to be somehow pertinent for the pediatric setting will otherwise be reviewed. Quality and evidence for or against each therapy will be evaluated according to the Scottish Intercollegiate Guidelines Network statement and practical reminders for clinicians will accordingly be provided.

Keywords: Acute lung injury, acute respiratory distress syndrome, children, neonatal critical care, the lung tissue, physiopathological background, pediatric, pharmacological therapy, pulmonary inflammation, respiratory failure