Title:Synthesis and Evaluation of Anti-Inflammatory and Antitussive Activity of Hydantion Derivatives
VOLUME: 9 ISSUE: 6
Author(s):Haibin Lu, Dejuan Kong, Bin Wu, Shihan Wang and Yongsheng Wang
Affiliation:College of Pharmacy, Jilin University; Ltd., No. 1266 Fujin Road, changchun, 130021, People’s Republic of China.
Keywords:Anti-inflammatory activity, Antitussive activity, Biological activity, Hydantoin, Ibuprofen, Synthesis
Abstract:1-Methylhydantion is a compound, which was isolated from Oviductus Ranae for the first time. In our study,
we found that it showed good antitussive and anti-inflammatory activity. It is also the first report which illustrates the
antitussive activity of hydantion derivative. A series of hydantion derivatives were synthesized and evaluated for their
anti-inflammatory and antitussive activity in vivo. The pharmacological tests showed that compounds 7a, 7c and 7d have
good anti-inflammatory and antitussive activity compared to Ibuprofen and codeine. Compound 7a in particular showed
two-fold stronger anti-inflammatory activity than Ibuprofen.
