Letters in Drug Design & Discovery

G. Perry
University of Texas
San Antonio, TX
USA
Email: lddd@benthamscience.org

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Synthesis, Antibacterial and Antifungal Activities of 3-Amino-5- methyl[1,1'-biphenyl]-2,4-dicarbonitrile Derivatives

Author(s): Khalid Mohammed Khan, Waqas Jamil, Nida Ambreen, Afroze Amyn, Summaya Saied, Maria Kanwal, Aqeel Ahmed, Shahnaz Perveen.

Abstract:

3-Amino-5-methyl-2,4-dicarbonitrile biphenyl derivatives 1-14 have been synthesized and all compounds were screened for their antibacterial effects against fourteen Gram-positive and sixteen Gram-negative bacterial strains and showed varying degree of activities. Compounds 1, 2, 4, 5, 6, 8, 13, and 14 were found to be significantly active against various Gram-positive bacteria, however, compounds 1, 3, 4, 6, 9, 12, and 13 were found to be significantly active against various Gram-negative bacterial strains. These compounds were also screened against fourteen fungal strains but showed weak activities against some fungal strains.

Keywords: 3-Amino-5-methyl-2, 4-dicarbonitrile biphenyl derivatives, Antibacterial, Antifungal

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Article Details

VOLUME: 9
ISSUE: 6
Year: 2012
Page: [618 - 624]
Pages: 7
DOI: 10.2174/157018012800672985
Price: $58