Thermal Inkjet Printing in Tissue Engineering and Regenerative Medicine
Xiaofeng Cui, Thomas Boland, Darryl D.D'Lima and Martin K. Lotz
Affiliation: Department of Molecular and Experimental Medicine, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.
With the advantages of high throughput, digital control, and highly accurate placement of cells and biomaterial
scaffold to the desired 2D and 3D locations, bioprinting has great potential to develop promising approaches in translational
medicine and organ replacement. The most recent advances in organ and tissue bioprinting based on the thermal
inkjet printing technology are described in this review. Bioprinting has no or little side effect to the printed mammalian
cells and it can conveniently combine with gene transfection or drug delivery to the ejected living systems during the precise
placement for tissue construction. With layer-by-layer assembly, 3D tissues with complex structures can be printed
using scanned CT or MRI images. Vascular or nerve systems can be enabled simultaneously during the organ construction
with digital control. Therefore, bioprinting is the only solution to solve this critical issue in thick and complex tissues fabrication
with vascular system. Collectively, bioprinting based on thermal inkjet has great potential and broad applications
in tissue engineering and regenerative medicine. This review article introduces some important patents related to bioprinting
of living systems and the applications of bioprinting in tissue engineering field.
Keywords: Gene transfection, growth factor, hydrogel, inkjet printing, microvasculature, photopolymerization, tissue engineering, CARTILAGE REPAIR, HUMAN MICROVASCULATURE FABRICATION
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