Abstract
This review provides a short overview of the most significant biologically oriented theories of human personality. Personality concepts of Eysenck, Gray and McNaughton, Cloninger and Panksepp will be introduced and the focal evidence for the heritability of personality will be summarized. In this context, a synopsis of a large number of COMT genetic association studies (with a focus on the COMT Val158Met polymorphism) in the framework of the introduced biologically oriented personality theories will be given. In line with the theory of a continuum model between healthy anxious behavior and related psychopathological behavior, the role of the COMT gene in anxiety disorders will be discussed. A final outlook considers new research strategies such as genetic imaging and epigenetics for a better understanding of human personality.
Keywords: COMT Val158Met, personality, genetic imaging, anxiety, anxiety disorders, catechol-o-methyltransferase, dopamine, Eysenck's personality theory, Behavioral Inhibition system, Fight flight freezing system, Panksepp's personality theory
CNS & Neurological Disorders - Drug Targets
Title:The Role of the Catechol-O-Methyltransferase (COMT) Gene in Personality and Related Psychopathological Disorders
Volume: 11 Issue: 3
Author(s): Christian Montag, Magdalena Jurkiewicz and Martin Reuter
Affiliation:
Keywords: COMT Val158Met, personality, genetic imaging, anxiety, anxiety disorders, catechol-o-methyltransferase, dopamine, Eysenck's personality theory, Behavioral Inhibition system, Fight flight freezing system, Panksepp's personality theory
Abstract: This review provides a short overview of the most significant biologically oriented theories of human personality. Personality concepts of Eysenck, Gray and McNaughton, Cloninger and Panksepp will be introduced and the focal evidence for the heritability of personality will be summarized. In this context, a synopsis of a large number of COMT genetic association studies (with a focus on the COMT Val158Met polymorphism) in the framework of the introduced biologically oriented personality theories will be given. In line with the theory of a continuum model between healthy anxious behavior and related psychopathological behavior, the role of the COMT gene in anxiety disorders will be discussed. A final outlook considers new research strategies such as genetic imaging and epigenetics for a better understanding of human personality.
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Montag Christian, Jurkiewicz Magdalena and Reuter Martin, The Role of the Catechol-O-Methyltransferase (COMT) Gene in Personality and Related Psychopathological Disorders, CNS & Neurological Disorders - Drug Targets 2012; 11 (3) . https://dx.doi.org/10.2174/187152712800672382
DOI https://dx.doi.org/10.2174/187152712800672382 |
Print ISSN 1871-5273 |
Publisher Name Bentham Science Publisher |
Online ISSN 1996-3181 |
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