On Chemical Structures with Potent Antiepileptic/Anticonvulsant Profile

Author(s): M. N. Aboul-Enein, A. A. El-Azzouny, O. A. Saleh, Y. A. Maklad.

Journal Name: Mini-Reviews in Medicinal Chemistry

Volume 12 , Issue 7 , 2012

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Abstract:

Epilepsy is a common chronic neurological disorder characterized by recurrent unprovoked seizures. There has been a considerable interest in the development of many antiepileptic and anticonvulsant agents for controlling epilepsy with fewer side effects and improvement of quality of life. Since the terms antiepileptics /anticonvulsants are used interchangeably, this article reviews their classification according to the chemical structure into: hydantoins, oxazolidinediones, succinimides, barbiturates, amides, benzodiazepines, valproic acid and its derivatives, GABAanalogues, cycloalkanes, semicarbazones, γ butyrolactones (GBLs), imidaquinazolines and pyrrolidine derivatives as well as miscellaneous compounds. In addition, the review discusses the different mechanisms of action of antiepileptic and anticonvulsant agents.

Keywords: Epilepsy, Mechanism of action of antiepileptics, Antiepileptics, Anticonvulsants, congenital, anticonvulsant, Tonic-Clonic Seizures, Generalized Seizures, Myoclonic Seizures, Benzodiazepines

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Article Details

VOLUME: 12
ISSUE: 7
Year: 2012
Page: [671 - 700]
Pages: 30
DOI: 10.2174/138955712800626665
Price: $58

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